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Discovery & Pre-Clinical/Clinical Development

Senior Associate Scientist, Translational Sciences-Immunology

  • Titel Senior Associate Scientist, Translational Sciences-Immunology
  • Functie Discovery & Pre-Clinical/Clinical Development
  • Sub functie Translational Discovery & Development Biomarkers
  • Categorie Experienced Scientist, Translational Discovery & Development Biomarkers (ST5)
  • Locatie San Diego, California, United States
  • Gepost
  • Referentie 2406187489W
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Beschrijving

Johnson & Johnson is currently seeking a Senior Associate Scientist to join our Translational Sciences (TS), Immunology Translational Sciences and Medicine (TSM) team located in San Diego, CA.

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/.Janssen Immunology has a history of bringing life-changing therapies to patients with immune-mediated diseases.

Translational Sciences and Medicine (TSM) is an integrated group of scientists composed of a clinical Translational Medicine (TM) team which conducts early clinical development and experimental medicine studies, and a Translational Sciences (TS) team which uses human based data and tissues to support the end-to-end portfolio. Together, the TSM group will provide the key learnings/insights on the next wave of novel therapies for patients. Organizationally, TSM serves as a pivotal bridge between Discovery Research and the later phase Clinical Development group. TSM provides the necessary scientific and clinical expertise to advance an industry-leading pipeline of novel mechanism small molecules and biologic agents to address unmet need in immune-mediated diseases.

TS has a broad remit stretching from support of discovery with human data to support target selection, through development of novel decision-making biomarkers for early phase clinical trials, target-centric indication sequencing and prioritization, and biomarker support of regulatory filings. The TS organization accomplishes these goals by integrating expertise in biomarker development, disease biology research and in the application of immunology and data science technologies to support drug discovery and development.

This position will reside within the ImmunoDermatology group in the Immunology Translational Sciences department and requires a highly motivated and skilled candidate to assist in the clinical progression of innovative therapies across diseases. The successful candidate will be responsible for conducting in vitro cellular assays and human biospecimen analysis to support immunology portfolio assets. The candidate will also conduct assay optimization and development, biomarker discovery and external collaboration biospecimen analysis to further Janssen leadership in immunodermatology. The candidate will bring an enthusiastic discovery mindset to Translational Sciences.

The Sr. Associate Scientist will be designing and conducting translational science research to support the Janssen immunology portfolio. He/she will conduct translational research to support clinical biomarker analysis, molecular and cellular profiling of therapeutic targets using primary human cells and in vitro cell based functional assays for mechanism of action studies. S/he will engage in the planning, execution, and interpretation of laboratory experiments. S/he will be conducting experiments with limited guidance and will be expected to collaborate with internal and external partners (CROs) on assay development and translational research. The candidate will also evaluate and optimize methods for novel platforms to enable multi-omics analysis of patient derived samples. Further, the candidate will operate in a highly collaborative environment and deliver high quality support for key stakeholders such as the Dermatology Disease Area Stronghold (DAS), and the Translational Science and Medicine team.

Responsibilities are as follows:

  • Clinical study samples management, processing, and analyses
  • Isolate and culture immune cells from skin and blood
  • Conduct ex vivo experiments and cell-based assays with primary human tissue and immune cells
  • Utilize various molecular biology lab methods, such as RNA extraction, protein extraction, immunoassays, qPCR, Nanostring, Olink platform to generate proteomic and transcriptomic data
  • Sample processing for scRNAseq, spatial transcriptomics
  • Preparation and/or staining of IHC/IF samples and analysis 
  • Execute research activities under limited supervision, provide critical analysis/interpretation of data
  • Provide project update and experimental findings in oral and written communication, including keeping accurate and detailed experimental record according to company guidelines
  • Contribute to conference posters and peer review publications
  • Work closely and collaboratively with other team members and maintain safety according to J&J EHS&S requirements to ensure optimal working environment (safety, culture)

Kwalificaties

  • Bachelor’s degree in a scientific discipline with at least 3-5 years of experience in biology, immunology or related experience OR a Master’s degree in a scientific discipline with at least 1 years of experience in biology, immunology or related experience is required
  • Detail oriented, highly organized multi-tasker with strong trouble-shooting skills
  • Experience in mammalian cell culture is required
  • Experience with the following molecular biology techniques/platforms is required: DNA/RNA/protein extraction, qPCR, NanoString, RNAseq and ELISA/MSD/Luminex/Singulex
  • Experience with histology, IHC/IF staining and analysis is preferred
  • Familiarity with designing, performing, and analyzing multicolor flow cytometry/FACS-based assay could be useful
  • Proactive, learning, troubleshooting and growth mindset
  • Background in inflammation or immunology research is strongly preferred

The anticipated base pay range for this position is $88,000 to $141,450.

Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.

Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).

This position is eligible to participate in the Company’s long-term incentive program.

Employees are eligible for the following time off benefits:

·       Vacation – up to 120 hours per calendar year

·       Sick time - up to 40 hours per calendar year

·       Holiday pay, including Floating Holidays – up to 13 days per calendar year

·       Work, Personal and Family Time - up to 40 hours per calendar year

Additional information can be found through the link below. For additional general information on Company benefits, please go to:  https://www.careers.jnj.com/employee-benefits

 Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

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