Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Sr. Associate Scientist to join a growing team focused on cell therapy process development for the development of innovative treatments for cancer. The position is a key part of the growing API Cell and Gene Therapy Organization located in Spring House, PA.
At the Janssen Pharmaceutical Companies of Johnson and Johnson, we are working to create a world without disease. Transforming lives by finding new and improved ways to prevent, intercept, treat and cure diseases inspires us. We bring together the best of minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research and Development, LLC is a part of the Janssen Pharmaceutical companies.
We are looking for an energetic, highly-motivated and collaborative Senior Associate Scientist candidate with demonstrated expertise in cell therapy process development and process innovation. In this role, the successful candidate will be involved in process design, unit operation development, and parameter optimization studies resulting in the development of new production processes. The successful candidate will work as part of a cross-functional teams supporting pre-clinical and clinical programs, focused on autologous processes. Primary responsibilities for this role include but are not limited to:
- Contribute to the design and help lead the successful execution of process development studies to develop and improve unit operations used for production of autologous T-cell therapies.
- Identify, critically assess and evaluate opportunities to improve manufacturing outcomes such as improving success rate, throughput, reducing cost, process time and product quality of the final drug product.
- Participate in design and help lead the execution of phase-appropriate process development studies identifying process parameters and appropriate ranges to be assessed for optimal experimental design of the study
- Contribute to the development of new autologous T-Cell therapeutics for clinical development, deliver robust and scalable processes for implementation in clinical MFG
- Directly support internal or CMO clinical manufacturing as/if required for troubleshooting, technology transfer and execution
- Work in a team and matrix environment as well as contribute individually to meet project timelines and deliverables
- Timely and thorough documentation and completion of electronic laboratory notebooks.
- Author reports detailing experimental work and summarizing results, protocols, technical reports and SOPs.
- Assemble and present research findings and data to the group•Support technology transfer activities, writing protocols, reports, and performing and coordinating activities to support successful manufacturing
- Maintain all individual training and safety requirements and participate in routine lab operations (maintenance, safety activities, calibrations)•Participate in routine lab operations (lab maintenance, safety inspections, etc) and maintain compliance with all appropriate SOPs for laboratory work, data recording, and laboratory equipment
- Other duties, as necessary
- MS in Biological Sciences, Biomedical Engineering or Immunology and with at least 4 years of industry experience OR a BS in Biological Sciences, Biomedical Engineering or Immunology and with at least 6 years of industry experience is required
Experience and Skills:
- Knowledge of biology/immunology/biochemistry as applied in cell and gene therapy processes (such as aseptic, cell culture, cellular metabolism, T-cell biology, cryopreservation) is required
- Knowledge and experience in CAR-T cell therapy, T cell biology, and fundamental immunology. Prior hands-on experience with equipment and unit operations typically used in process development and manufacture of cell therapy products is required
- Ability to Independently design, execute and troubleshoot experiments, analyze, report and present data
- Must be detail-oriented, highly organized and able to manage multiple tasks, handle tight timelines and deliver quality data
- Experience in maintaining written records of work in the form of laboratory notebooks (paper or electronic) and establishing lab protocols/SOPs is required
- Have deep intellectual curiosity, and excellent communication, interpersonal and collaborative skills
- Must be comfortable handling and processing blood or serum samples
- Occasional weekend work may be required
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.