Computational Immunologist, Immunology Data Science

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Job Description

Janssen Research & Development is a world-class pharmaceutical organization committed to research and development of innovative therapies for diseases with great unmet medical need.  Janssen Immunology Research & Development focuses on improving the health and lifestyles of people with serious immunological and inflammatory conditions worldwide, and today has a leading portfolio of medicines to treat psoriasis, Crohn’s disease, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, atopic dermatitis and ulcerative colitis.


Data science is a critical function within Janssen Immunology supporting drug discovery and development. The Immunology Data Science team contributes to many aspects of drug development including exploration of molecular data to discover and validate biological pathways, data management and development of advanced analytics, and application of real-world evidence to drug development strategies.


This role is within Immunology Data Science on the Translational Data Science (TDS) team. TDS is responsible for partnering closely with Immunology Discovery to provide data science support throughout the drug discovery process. Activities include partnering with discovery scientists to mine human molecular data for novel pathways, identify therapeutic targets within pathways of interest, and analyze molecular data from preclinical experiments to progress discovery programs. Strategically, TDS adds value to the pipeline by bringing human molecular data to bear early in the drug discovery process and, in doing so, builds strong rational for relevance to human disease and prospective patient stratification.


The successful candidate will collaborate closely with discovery immunologists to identify new disease pathways from human molecular data, build human disease and stratification rational and analyze preclinical molecular data. The candidate must have deep technical background in computational biology and extensive experience applying that background to the study of complex biological systems. In addition, given the collaborative nature of this role, exceptional communication and collaboration skills and an excellent ability to build relationships are critical.



Integrate on to multifunctional discovery teams and identify scientific questions addressable using computational approaches

Develop and execute computational analysis plans in partnership with discovery immunologists in support of key scientific objectives

Drive interpretation of analysis results and how these results will affect strategic direction of discovery team

Contribute to experimental design in partnership with discovery immunologists to test hypotheses generated from computational analysis

Monitor and evaluate emerging approaches to predicting disease biology including methods for causal inference and data mining

Continue to develop technical expertise as a computational biologist by identifying emerging skillsets and attending appropriate training

Build strong relationships with the scientific community and external innovators to ensure we are deploying the very best computational approaches

Drive technical excellence and robustness in computational analysis in particular for analyses that will drive strategic decisions


2-4+ years post-graduate industry experience

PhD degree in Immunology, Biology, Computational Biology, Genomics or related field

Extensive experience gaining biological insights using computational approaches and high-dimensional biological data (e.g., transcriptomics, genomics, etc.) 

Extensive experience using coding languages (such as Python or R) to analyze biological data

Experience within the immunology field or a closely related field of biology

Exceptional communication and collaboration skills

Experience analyzing single cell sequencing data is highly preferred

Experience in wet lab techniques and the generation of biological data is a plus

Experience navigating a matrixed organization is a plus

Primary Location
United States-Pennsylvania-Spring House-
Janssen Research & Development, LLC (6084)
Job Function
Digital Product Development
Requisition ID