Principle Scientist, Computational Toxicology - (US or Belgium) Janssen Research & Development, LLC

Get Referred

Job Description

Principle Scientist, Computational Toxicology


Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Principal Scientist, located in Beerse, Belgium, Springhouse, PA or  La Jolla, CA. 


At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science.  


We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at and follow us @JanssenGlobal.  Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies. 


Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit for more information.  

We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it. Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer.

We are seeking a motivated computational toxicologist for a scientific position in the Predictive & Investigative Toxicology Group within the Nonclinical Safety (NCS) function. The successful candidate will have strong computational (in silico, data sciences, chemoinfomatics) toxicology experience. She or he will have strong leadership, communication, and networking skills to support the global function.  The principle scientist will apply computational toxicology and chemo-informatic approaches to preclinical safety assessment. She or he will apply modeling approaches to understand and improve drug de-risking and safety prediction in support of early pipeline decision making. This position can be based in Beerse, Belgium, Springhouse, PA or  La Jolla, CA.

Key Responsibilities:

  • Building QSAR, probabilistic and machine learning models to predict potential off-target activities of drugs, provide new mechanistic hypotheses and inform priorities for in-vitro and in-vivo assessment.
  • Extract large internal and external datasets, including data handling, processing and model building.
  • Contribute to progression of ongoing computational approaches, advanced machine learning and participate in the development of new solutions to be used in non-clinical safety.
  • Implement predictive toxicology approaches early-on to influence selection of high-quality chemical series.
  • Build collaborative partnerships across NCS to address computational toxicology needs and gaps.
  • Participate in or lead strategically aligned external groups relevant to computational toxicology. 
  • Stay abreast with new developments in the field.
  • Work adaptively and flexibly with colleagues across sites spanning the globe in Janssen R&D and NCS. 




  • PhD in toxicology, pharmacology, chemistry with experience in computational toxicology and/or chemoinformatics.  
  • At least 6 years of work experience in pharmaceutical company (MS with 10 years or BS with 12 years exp in pharmaceutical company considered). 
  • Established expertise in computational toxicology is required. 
  • Proficiency in either Python, JavaScript, MatLab, or R is highly prefrred. 
  • High performance computing is a plus 
  • Familiarity with structured and unstructured data sources is required 
  • Strong written and oral presentation skills with a record of publications in peer-reviewed journals and invited presentations  
  • Self-motivated with a high level of autonomy 
  • Strong interpersonal skills with a collaborative mindset 
  • Travel up to 20% both domestic and internationally is required


Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.


Primary Location
United States-California-La Jolla-
Other Locations
North America-United States-Pennsylvania-Spring House, Europe/Middle East/Africa-Belgium-Antwerp-Beerse
Janssen Research & Development, LLC (6084)
Job Function
Requisition ID