Johnson & Johnson Careers

DMPK BIOTRANSFORMATION POSTDOCTORAL FELLOW

San Diego, California
R&D


Job Description

Requisition ID: 8903190314

Caring for the world, one person at a time has inspired and united the people of Johnson & Johnson for over 130 years. We embrace research and science -- bringing innovative ideas, products and services to advance the health and well-being of people.

 

With $76.5 billion in 2017 sales, Johnson & Johnson is the world's most comprehensive and broadly-based manufacturer of health care products, as well as a provider of related services, for the consumer, pharmaceutical, and medical devices markets. There are more than 250 Johnson & Johnson operating companies employing over 125,000 people and with products touching the lives of over a billion people every day, throughout the world. If you have the talent and desire to touch the world, Johnson & Johnson has the career opportunities to help make it happen.

 

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

 

Janssen Research & Development L.L.C., a member of Johnson & Johnson's Family of Companies, is recruiting a motivated and enthusiastic individual to join the DMPK group as a Postdoctoral Fellow in San Diego, CA to contribute to research on drug-induced liver injury (DILI), a significant reason for drug attrition.

 
A large body of evidence suggests that drugs capable of forming reactive metabolites (RMs) are associated with DILI. The primary responsibility of the candidate is to study the formation of reactive metabolites using novel in vitro systems combined with state-of-the-art high resolution liquid chromatography tandem mass spectrometry (LC-MS/MS) systems to enhance safety assessment for drug molecules, particularly in the drug discovery setting. The candidate will conduct in vitro biotransformation studies to determine the metabolic pathway, mechanism, and structural identity of metabolites. A key object of this position is to develop, validate, and implement new assays and analytical methods (e.g.LC-MS and data analysis) to translate to positive clinical outcomes. The results from these studies will offer new tools and insights for DMPK to better support drug discovery programs, and findings will be encouraged to be published in scientific conferences and/or peer-reviewed journals.

Qualifications
  • PhD degree in biochemistry, medicinal chemistry, analytical chemistry, or other relevant discipline is required.
  • Candidates must be available to work full-time.
  • Candidates must be legally authorized to work in the United States and not require sponsorship for employment visa status (e.g. H1-B status) now or in the future. 
  • Previous small molecule LC-MS/MS structural identification experience is required
  • Good understanding of drug metabolism concepts is required
  • Strong data analysis skills are desired
  • Excellent interpersonal, organizational, oral/written communication and teamwork skills are required.
  • Candidates must be detail-oriented, highly organized and able to manage multiple tasks.
  • Candidates must have the ability to work individually (independently) as well as on a team.
  • Record of accomplishment as evidenced by first-author and co-authored publications in scientific journals

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.


Primary Location
United States-California-San Diego-
Organization
Janssen Research & Development, LLC. (6084)
Job Function
R&D
Requisition ID
8903190314