Johnson & Johnson Careers

Senior Scientist, Pharmacometrics

Spring House, Pennsylvania
Pharmacokinetics


Job Description

Requisition ID: 8809190305

Janssen Research & Development, L.L.C., a Johnson & Johnson company, is recruiting a Senior Scientist, Pharmacometrics to be located in Spring House, PA.

Janssen Research & Development, L.L.C. develops treatments that improve the health and lifestyles of people worldwide. Research and development areas encompass novel targets in neurologic disorders, gastroenterology, oncology, infectious disease, diabetes, hematology, metabolic disorders, and immunologic disorders.

Janssen Pharmaceuticals, Inc., a pharmaceutical company of Johnson & Johnson, provides medicines for an array of health concerns in several therapeutic areas, including Oncology/Hematology, Immunology, Cardiovascular and Metabolic Diseases, Neurologic Diseases, Infectious Diseases and Vaccine. Our ultimate goal is to help people live healthy lives. We have produced and marketed many first-in-class prescription medications and are poised to serve the broad needs of the healthcare market – from patients to practitioners, from clinics to hospitals. For more about Janssen Pharmaceuticals, Inc., one of the Pharmaceutical Companies of Johnson & Johnson, visit www.janssenpharmaceuticalsinc.com

The Senior Scientist (Pharmacometrics) will conduct advanced PK/PD translational modeling research with emphasis on disease progression modeling and implementation of mechanism-based approaches. Will support product development as Pharmacometrics Leader by defining the dose-concentration-pharmacological effect relationships of drugs using modeling and simulation methodologies from data acquired at various stages of drug research and development. Perform basic and clinical disease research, with a focus on Immunology and Oncology/Hematology compounds (both small molecules and biologics). Perform population PK and PK/PD analysis for key dose/regimen selections and regulatory submissions. The successful candidate uses state-of-the-art computer modeling and simulation techniques to formulate various clinical trial design scenarios and outcome analyses. Will have full technical responsibility for interpreting, organizing, executing, and coordinating assignments. Conceptualize plan, develop and execute R&D projects that have a major impact on key development programs, and acts as the Pharmacometrics Leader on Clinical and/or Compound Development Teams. Actively maintain relationships and collaborate with colleagues within or outside the Clinical Pharmacology and Pharmacometrics organization and J&J at large. Will be responsible for acting independently on scientific and technical matters pertaining to his/her field, to drive advancing the science in the field, to identify research opportunities and to coordinate them.

Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer.

Qualifications

A minimum of a Master’s degree in Pharmaceutical Sciences, Clinical Pharmacology, Chemical/Biomedical Engineering or related discipline with a minimum of 5 years of pharmaceutical development experience in various aspects of modeling and simulation is required OR a PhD in Pharmaceutical Sciences, Clinical Pharmacology, Chemical/Biomedical Engineering or related discipline with a minimum of 2 years of pharmaceutical development experience in various aspects of modeling and simulation is preferred.

Hands-on experiences with population approach in describing PK/PD systems with various types of clinical pharmacology data is required.

Demonstrated experience identifying research projects and successfully managing them in collaboration with internal or external teams is required.

In-depth knowledge of preclinical or clinical pharmacokinetics, drug metabolism, PK/PD modeling principles and statistics is required.

Experience with NONMEM, R and/or other modeling and simulation software is required.

Thorough knowledge of planning, conducting, evaluating and reporting PK/PD studies in R&D is required

The ability to perform basic and clinical disease research, with a focus on Oncology/Hematology and/or Immunology compounds is preferred.

Excellent communication and interpersonal skills is required.

Experience with biologics drug development is preferred but not required.


Primary Location
United States-Pennsylvania-Spring House-
Organization
Janssen Research & Development, LLC. (6084)
Job Function
Pharmacokinetics
Requisition ID
8809190305