Scientist, Oncology In Vivo Pharmacology - Colorectal Cancer Interception

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Job Description

Janssen Research & Development, LLC, a member of Johnson & Johnson's Family of Companies, is recruiting for a Scientist, Oncology In Vivo Pharmacology - Colorectal Cancer Interception, located in Spring House, PA.


At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives.  We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found. 


Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases.  Please visit for more information.


The Scientist will support pre-clinical drug discovery programs for Colorectal Cancer Interception within the Oncology Therapeutic Area of Janssen.  This individual will join the In Vivo Pharmacology group efforts in the pharmacological characterization and development of small molecules and biologics, including those that function as immune modulators for the prevention and treatment of colorectal cancer.  Independently drive in vivo and ex vivo oncology studies for colorectal cancer research programs across the different stages of preclinical drug discovery.  Experimental work is an important part of the role and this individual will spend a significant part of their time at the bench, demonstrating rigorous data documentation and analysis skills.


Principal Responsibilities:

  • Independently design, execute, and interpret  complex in vivo studies for the validation and characterization of targets or therapeutic agents in the areas of oncology and tumor immunology, including efficacy and pharmacokinetic/pharmacodynamics (PK/PD) biomarker studies in rodents.

  • Establish and perform in vivo model development, including the improvement, adaptation, or change to existing research methods.

  • Develop research solutions that require extensive analyses and detailed investigation.

  • May perform bioluminescent imaging studies using molecular reporters or disseminated/metastatic disease models.

  • May contribute to ex vivo analysis of tumor or immune cells by flow cytometry, IHC, ELISA, RT-PCR, or Luminex.

  • Manage multiple in vivo projects simultaneously, including working within a matrixed research environment to coordinate with project leaders and other functions.

  • Analyze data using appropriate statistical methods and present data in a professional format suitable for external publication.

  • Contribute to various projects, collaborate with stakeholders from all relevant functions, and keep up-to-date in the literature related to their field.

  • Act as an expert resource on project teams and demonstrate clear and professional verbal and written communication.

  • Initiate and maintain external collaborations (Contract Research Organizations (CROs), academics, etc.).

  • A minimum of a Bachelor’s degree in Life Sciences (Cellular/Molecular Biology, Pharmacology, Tumor Immunology) is required.  Master’s or Ph.D. degree in Life Sciences preferred.
  • A minimum of 9 years of related colorectal cancer in vivo pharmacology experience with a Bachelor’s degree; a minimum of 6 years of related experience with a Master’s degree; or a minimum of 3 years of related experience with a PhD degree is required.
  • Experience with the cell culture of cancer or immune cells is preferred.
  • Experience with relevant colorectal cancer rodent models, including genetically engineered tumor models such as APC min, is required.
  • Experience with xenografts, syngeneic models, primary grafts, orthotopic models and humanized models preferred.
  • Experience with small molecules and/or biologics preferred.
  • Experience with vaccines is preferred.
  • Experience with tumor implantation techniques and dosing (po, iv ip, routes), tumor measurement, health monitoring, and data collection and analyses required.
  • Experience with bioluminescent imaging, flow cytometry, IHC, ELISA, RT-PCR, Westerns, and/or Luminex preferred.
  • Experience with the adherence to animal welfare and compliance regulations is required.
  • Experience in writing technical drafts for patent filings, IND (US-FDA) or CTA (EMA) filings preferred.
  • Project leadership experience is preferred.
  • Must have excellent verbal and written communication skills.
  • Must have excellent interpersonal skills, with the ability to interact effectively with people, internally and externally.
  • Must have strong data management, analyses, and record-keeping skills.
  • The ability to effectively present scientific data and concepts to colleagues and teams and present at external meetings is required.
  • This position will require occasional weekend, evening, and holiday dosing/animal monitoring.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer.  All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Primary Location
United States-Pennsylvania-Spring House-
Janssen Research & Development, LLC (6084)
Job Function
Requisition ID