Johnson & Johnson Careers
DMPK Mechanistic Modeling/Assay Development – Postdoctoral Researcher
Requisition ID: 7797190215
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Janssen, a member of Johnson & Johnson's Family of Companies, is recruiting a PK/PD Modeling and In Vitro Assay Post-doctoral Intern. The internship is offered by the Drug Metabolism and Pharmacokinetics (DMPK) group within the Discovery, Product Development and Supply group of Janssen. The DMPK group supports discovery and development of therapies for a range of indications including oncology, cardiovascular, metabolic, neurological and immunological diseases.
The focus of this internship will be to drive forward the relatively underdeveloped science of intestinal stability and absorption of peptides/peptidomimetic drugs. While many peptides cannot be developed for oral use due to low intestinal absorption rates and high gut instability, exceptions exist (e.g. cyclic peptides). Through mechanistic gut and PBPK modeling of existing data, as well as in vitro/in vivo assay development, the postdoctoral intern will improve our understanding of what drives peptide stability and absorption and how to apply this to drug discovery and development programs.
The Postdoctoral Intern will:
- Work with PBPK/PK-PD modelers to develop techniques to understand gut tissue exposure and systemic absorption of peptides.
- Collaborate with in vitro and in vivo scientists to develop assays appropriate for peptides and translatable to the clinic.
- Collaborate with internal and external experts to leverage knowledge and data from all available sources.
- Candidates must be enrolled in an accredited college/university pursuing a PhD in mathematical modeling, biology, chemistry, biochemistry or a related discipline, or recently have completed their Ph.D. in these areas (<2 years).
- Candidates must be available to work Full-time).
- Candidates must be legally authorized to work in the United States and not require sponsorship for employment visa status (e.g. H1-B status) now or in the future.
- Demonstrated leadership including publication of high impact, peer-reviewed publications is required.
- Candidates must be detail-oriented, highly organized and able to manage multiple tasks.
- Candidates must have the ability to work individually (independently) as well as on a team in a matrix environment.
- Candidates must be proficient with Microsoft Office, Word, Excel (including a high proficiency with generating pivot tables and graphs), and Power Point, and have strong oral and written communication skills. Additional technical competencies in SharePoint and other information technology systems are highly desirable, as is experience with PubMed databases and other literature databases.
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
United States-Pennsylvania-Spring House-
Janssen Research & Development, LLC. (6084)