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Job Description

Janssen Pharmaceutical, a member of Johnson & Johnson's Family of Companies, is recruiting for a Principal Scientist. The position will be located in Spring House, PA. 

At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found. 

We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it. 

The primary responsibility for this individual will be to lead a team of biologists that define and prosecute projects that deliver high quality clinical candidates. The Principal Scientist will be a part of a broader team focused on adaptive immune mechanisms in Immunology Discovery. This individual will provide scientific leadership within the Adaptive Discovery team and interface with internal and external partners to discover novel therapeutics to treat autoimmune diseases. Emphasis is placed on development and execution of in vivo experimental approaches to address pharmacological and biological hypothesis and advance drug candidates.

People management including coaching, mentoring and managing people for performance and scientific growth is a key aspect of this position. Additional responsibilities include but are not limited to: 

• Work independently, manage and mentor scientists doing cutting edge research, design experiments, interpret data, troubleshoot and suggest next steps, detail-oriented with strong organizational skills 

• Collaboratively work in a matrix environment, present ideas, both verbally and in writing to diverse audiences including scientific colleagues and senior leadership 

• Work in a collaborative environment where ideas can be respectfully challenged to drive excellence and innovation

  • PhD in Immunology, Pharmacology, Immuno-oncology or Virology with at least 5-7 years of pharmaceutical industry or in vivo pharmacology CRO experience with progressively advanced responsibilities is required; Post-doctoral training is preferred.
  • Demonstrated success as an in vivo pharmacologist/scientist, with a proven track record of good experimental design, in-depth data analysis and interpretation on strong scientific rationale and understanding of pharmacological concepts (efficacy, PK/PD relationships) is required. 
  •  An ability to conduct in vivo studies, if needed, or train team members on in vivo techniques is required. 
  • Experience with ancillary in vitro and ex vivo assays to characterize PD or target engagement effects of experimental medicines (multi-color flow cytometry, T cell/B cell cultures, cytokine/inflammatory mediator assessment (ELISA, MSD, WB etc) is required.
  • Previous supervisory experience of PhD level and non-PhD-level scientists is preferred. 
  • Experience leading/ advancing drug discovery programs in immune-mediated diseases is required, with previous experience in autoimmune diseases strongly preferred.
  • Strong written and oral communication skills to diverse audiences including scientific colleagues and leadership, and an ability to provide fit-for-purpose communication in the context of a multidisciplinary team are required.
  • Position located in Spring House, PA and may require up to 10% travel.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. 


Primary Location
United States-Pennsylvania-Spring House-
Janssen Research & Development, LLC (6084)
Job Function
Requisition ID