Johnson & Johnson Careers

Principal Scientist Biotransformation

Spring House, Pennsylvania

Job Description

Requisition ID: 7007190613

Johnson & Johnson is recruiting for a Senior Scientist, Biotransformation, located in Spring House, PA.
At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at and follow us @JanssenGlobal.
The Drug Metabolism and Pharmacokinetics (DMPK) Division, which is part of Discovery Sciences at Janssen Pharmaceutical R & D, is seeking a highly motivated and talented Biotransformation Scientist to provide drug metabolism support for drug discovery and development programs at its Spring House site in PA. The position will have hands-on lab-based activities including crafting and conducting various drug metabolism experiments, interpretation of data, presenting data to team and writing reports. Responsibilities include:
You should have extensive hands-on experiences using various biochemical (incubation with various liver subcellular fractions, recombinant enzymes, and hepatocytes) and analytical (LC-radioactivity detector-tandem mass spectrometry) techniques to support in vitro and in vivo drug metabolism studies, automated sample preparation, experience with determination of kinetic parameters of metabolite formation, and hands-on operation and troubleshooting of Thermo Scientific and Bruker LC-MS instruments. Prior experience in using high resolution accurate LC-MS in Omics or MALDI imaging application is a plus. You should have excellent communication skills and ability to translate into information at internal/external meetings and writing skills to prepare reports/manuscript for publication. You are expected to multitask, possess the ability to work well in a multidisciplinary team and be highly flexible in a dynamic environment. You should have a working knowledge and broad experience in the optimization of ADMET properties of potential drug compounds in the discovery setting. This includes providing structure-metabolism/bioactivation-relationship to minimize metabolic clearance or reactivity to move project to development. The individual is expected to perform some research by collaborating with researchers internally or externally.

  • Ph.D. in Medicinal Chemistry or Biochemistry or Pharmaceutical Sciences with 1 year of relevant post-doctoral experience or an M.Sc degree with a minimum of 8 years of direct industrial drug metabolism experiences is required.

  • Some supervisory experience is preferred.

  • Proven experience in qualitative and quantitative drug metabolism as supported by relevant publications in peer-reviewed journals and presentations in conferences is required.

  • Strong organizational and problem-solving skills is required

  • Working knowledge of enzymology is preferred.


Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Primary Location
United States-Pennsylvania-Spring House-
Janssen Research & Development, LLC (6084)
Job Function
Requisition ID