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Senior Scientist – CVM Biology Integrative Sciences, Statistical Genetics

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Job Description


Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Senior Scientist, located in Spring House, PA

 

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science.

 

We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal.  Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

 

The Senior Scientist will identify novel therapeutic targets and biomarkers from the investigation of human genetic variation (GWAS, Next Gen Sequencing) with disease status and intermediate variables using cutting-edge techniques in Statistical Genetics. They will develop and apply methods for the integration of GWAS summary results with other types of data e.g. Metabolomics/mQTL, eQTL, functional genomic annotations, gene networks, estimation/partitioning of heritability, Mendelian Randomization to understand causal direction, and fine mapping. Additional responsibilities include:

  • Collaborate with experimental, clinical and bioinformatic scientists to address target mechanism specific questions and interpret efficacy and safety insights derived from PheWAS/association data and seek to support investment decision making with genomic insights
  • Uncover opportunities for therapeutic translation and biomarkers of disease heterogeneity, progression, and treatment response from genetic data sources including clinical trials, precompetitive consortia, academic collaborations or population biobanks
  • Will initiate and drive strategic external collaborations supporting these goals


Qualifications
  • PhD in the field of statistical genetics, bioinformatics, epidemiology or biostatistics with at least 3 yrs of experience in an industry research environment is required

  • Postdoctoral experience is preferred

  • Track record of genomic discovery in large scale GWAS and WES/WGS datasets in academia and/or industry with electronic health record derived phenotypes is preferred

  • Knowledge of the range of genome-wide and phenome-wide analysis approaches, encompassing genotype and sample q.c., phenotype evaluation, imputation and methods to address relatedness, population structure, case-control imbalance is required

  • Hands-on experience in the design, execution, and quality control of association analyses in large WES/WGS and GWAS datasets is preferred

  • Experience with statistical computing in R expected with familiarity of aggregated marker methods (e.g. burden, SKAT, VT) and large-scale genetic analysis approaches (e.g. PLINK, HAIL, EPACTS, METAL/RAREMETAL) is preferred

  • Experience in fine-scale locus dissection and in causal inference from individual-level and summary association data is preferred

  • Familiarity with Cardiovascular, Diabetes & Metabolism research and biology, target identification and therapeutic development is preferred

  • Knowledge of biological mechanisms and application of computational biology methods (preferably in the biotech/pharmaceutical industry) is preferred

  • Ability to write manuscripts for publication and has maintained a record of high-quality peer reviewed publications and oral presentations in a relevant field

  • Understanding of the overall process of drug discovery and development is preferred
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
Primary Location
United States-Pennsylvania-Spring House-
Organization
Janssen Research & Development, LLC (6084)
Job Function
R&D
Requisition ID
6494190606