Johnson & Johnson Careers

Principal Scientist, Lead Molecular Engineering and Automation

Spring House, Pennsylvania

Job Description

Requisition ID: 6202190131

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Principal Scientist, Lead Molecular Engineering and Automation located in Spring House, PA.
At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at and follow us @JanssenGlobal.  Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.
The Principal Scientist position in Lead Engineering is a leadership position within the Biologics Discovery team.  The successful candidate will drive biologics discovery in partnership with different therapeutic areas (TA) including oncology, immunology, metabolic diseases, neurology and infectious diseases. As a scientific leader in the department, the Principal Scientist will interact with other functional areas to design and implement high-throughput protocols and automation targeting antibody & other biological therapeutics, such as CAR-Ts. The positions responsibilities also include therapeutic portfolio project leadership in a matrixed organization and innovation by adding cutting-edge automation to the multi-specific workflows.   The scope of this position encompasses:
  • Lead a team to design sequences and building of universally compatible vectors to support all large molecule, cell- and viral-based therapeutics
  • Develop novel antibody-based technologies to expand the throughput within multi-specific and CAR-T engineering
  • Design and implement an automation plan for Lead Engineering that meets Janssen Biotherapeutics current and future needs
  • Building automation to streamline antibody, multi-specific format workflows
  • Leading portfolio project(s) from idea through IND-readiness in partnership with therapeutic area leadership
  • Lead and execute molecular biology, such as in silico sequence fitness assessments, PCR-based cloning, construct design, library and/or site-directed mutagenesis strategies for the biologics portfolio
  • Developing workflows for high-sensitivity, high-throughput assays (protein and/or cell-based) for antibody and cellular therapeutics to select leads with excellent biophysical and manufacturing properties with reduced immunogenic potential
  • Leading and supervising research activities of bench scientist(s)
  • Presenting and defending scientific findings in cross-functional project teams/initiatives, drafts protocols and reports

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Primary Location
United States-Pennsylvania-Spring House-Welsh & McKean Roads
Janssen Research & Development, LLC. (6084)
Job Function
Requisition ID