Johnson & Johnson Careers

POSTDOCTORAL FELLOW-AAV ENGINEERING, PROMOTER DESIGN AND PRODUCTION DEVELOPMENT

Spring House, Pennsylvania
Administration


Job Description

Requisition ID: 6056181030

Janssen BioTherapeutics is seeking a highly motivated individual to support development of AAV production platforms, capsid engineering, and vector technology in which to leverage this knowledge to improve our AAV gene therapy program.

 

For consideration as a post-doctoral fellow, the successful candidate will be a subject matter expert on the development of AAV-based gene therapies.  The candidate will have experience in viral vector design, characterization, and production platforms.  The position will be responsible for developing novel capsid engineering for improving target cell tropism as well as characterizing viral vectors in support of gene therapies across a broad range of targets.  Towards this end, a fundamental understanding of evaluating expression profiles of therapeutic targets will be required.  The ability to interact with external stakeholders and to subsequently apply that knowledge towards developing a world-class gene therapy program is critically important

At Janssen, postdoctoral fellows are trained by expert scientists working at the cutting edge of drug discovery.  Janssen Bio Therapeutics supports a wide range of therapeutic areas including Oncology, Neuroscience, Cardiovascular and Metabolism, Immunology, and Infectious Diseases.  The successful candidate will learn from and contribute to an industry-leading drug discovery program that has brought numerous quality therapeutics to patients and significant contributions to human health.  They will partner throughout the Janssen R&D organization and participate in cross-functional team discussions, gaining insight into many aspects of biotherapeutic discovery and development.  The Postdoctoral Fellow is expected to author papers on their research and present novel findings at scientific conferences. 

Key Objective:

To use state-of-the-art cell engineering, gene expression technologies, and protein purification methods to gain a better understanding into basic AAV biology and viral production systems. 



Qualifications
Qualifications

Suitable candidates should be highly motivated, independent thinkers with a Ph.D. in virology, molecular or cell biology, cell engineering or a related field.  Research experience or knowledge in one or more of the following areas is preferred:

  • Gene editing technologies such as CRISPR or CRISPR screening
  • Basic molecular techniques with excellent working knowledge of how to work with protein and nucleic acids.
  • Knowledge of AAV capsid structure or design approaches
  • Knowledge of AAV Biology
  • Experience working with AAV
  • Excellent cell culture skills

Candidates must display an ability to independently design and execute research.  In addition to a broad knowledge of cell and molecular biology, we are seeking an individual with deep intellectual curiosity, and excellent communication and interpersonal skills.




Primary Location
United States-Pennsylvania-Spring House-
Organization
Janssen Research & Development, LLC. (6084)
Job Function
Administration
Requisition ID
6056181030