Johnson & Johnson Careers
Scientist Biology, Pulmunary Arterial Hypertention
Requisition ID: 5672190128
Janssen Research & Development, L.L.C., a Johnson & Johnson company, is recruiting for a Scientist to be located in Spring House, PA.
Janssen Research & Development, L.L.C. develops treatments that improve the health and lifestyles of people worldwide. Research and development areas encompass novel targets in neurologic disorders, gastroenterology, oncology, infectious disease, diabetes, hematology, metabolic disorders, immunologic disorders, and reproductive medicine.
The Scientist will support drug discovery of novel therapeutics for pulmonary arterial hypertension while exploring the impact of heart failure and fibrosis (cardiac and lung) on pulmonary hemodynamics. The position is a lab-based role and the successful candidate will have a background in the cardiovascular disease area, an understanding of the pathophysiology of pulmonary arterial hypertension, cardiac dysfunction and fibrosis and the ability to manage their work independently. The primary responsibility of the Scientist is to provide scientific and technical support for conducting research involving in vitro and in vivo preclinical studies.
The qualified Scientist needs to independently plan and execute in vitro and ex vivo experiments, to develop and follow protocols, to document data, to troubleshoot problems, and to interpret data and communicate results. Responsibilities include scientific leadership, study planning, hands-on study execution, analysis, troubleshooting and documentation according to best business practices. The Scientist will use emerging developments in the cardiovascular field to generate novel target ideas and provide technical and strategic input with the goal of progressing novel drug candidates into clinical development and beyond.
- Working knowledge of pharmacology and/or drug discovery principles is required.
- Pro-actively investigate, improve, change or adapt existing methods and techniques.
- Work in cross-functional teams, including program project teams and disease-specific working groups, with representatives from other discovery functions, translational medicine and biomarkers, to shape a discovery and pharmacology strategy for novel drug candidates and bring forward novel translational animal models and innovative technologies to support long-term plans.
- Collaboratively work in a matrix environment, present ideas, both verbally and in writing to diverse audiences including scientific colleagues and senior leadership.
- Present scientific accomplishments internally and externally to the scientific community and discuss ideas with key opinion leaders.
- Demonstrated skills in performing pharmacological and mechanistic studies in models of cardiovascular diseases is required.
- Experience with cell culture, assay development, immunoassays including Western blotting, ELISA, and/or MSD is required.
- Expertise in the area of pulmonary arterial hypertension and hemodynamic assessments is preferred.
- Experience in industry is preferred.
- Expertise with pre-clinical inhaled delivery including experience with different delivery modalities (nebulized and dry powder, inhaled and intratracheal) is preferred..
- Peer reviewed publication record in relevant fields is required.
United States-Pennsylvania-Spring House-
Janssen Research & Development, LLC. (6084)