Senior Associate Scientist, Biophysical Screening

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Job Description

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Senior Associate Scientist, Biophysical Screening   located in Spring House, PA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at and follow us @JanssenGlobal.  Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.


The candidate will work as part of the High-Throughput Precursor Screening team to support Biologics Discovery pipeline across all therapeutic areas of J&J. The main responsibility includes the use of screening methods such as Surface Plasmon Resonance (SPR), Hydrogen Deuterium Exchange Mass Spectrometry (HDX-MS), and Differential Scanning Fluorimetry (DSF) to deliver quality data that enable hit-to-lead selection. Key objectives for this position involve the implementation of the Quality of Antibody Response (QAR) workflow using established biophysical methods to analyze the antibody response from various immunization campaigns with regard to affinity and epitope diversity, and the execution of thermal ramp stability measurements to characterize antibody hits that meet the target molecule profile for a given therapeutic indication.

Key Responsibilities:

  1. Design and perform fit-for-purpose laboratory experiments using high-throughput SPR and DSF to characterize antibody candidates.

  2. Streamline screening workflows and develop automated laboratory processes and instrumentation systems for expanded throughput capability.

  3. Work closely with Antibody Generation group within the Biologics Discovery regarding process improvement and new technologies.

  4. Communicate results to JBIO project teams and management.




Master’s degree in Biochemistry, Biophysics, Biotechnology, Biochemical Engineering, or related field with 2-6 years of scientific experience in the pharmaceutical/biotechnology industry OR Bachelor’s degree with 4-9 years of relevant experience.

Experience and Skills:


  • Ability to handle large amount of dataset and produce high quality results with quick turnaround time.
  • Experience with high-throughput screening and basic competence with biophysical techniques such as SPR, DSF/DSC, etc.
  • Broad understanding in state-of-the-art biophysical technologies.
  • Strong collaborative and interpersonal skills and an ability to perform in the context of multidisciplinary teams.
  • Strong written and oral communication skills.
  • Integrity, curiosity, rigor, and self-motivation to drive assigned projects to sound scientific conclusion.


  • Experience with Mass Spectrometry is plus.
  • Experience in Biologics Discovery


Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability

Primary Location
United States-Pennsylvania-Spring House-Welsh & McKean Roads
Janssen Research & Development, LLC (6084)
Job Function
Requisition ID