Johnson & Johnson Careers

Scientist In Vivo Pharmacology, Pulmonary Arterial Hypertension, Cardiovascular & Metabolism Discovery

Spring House, Pennsylvania

Job Description

Requisition ID: 5670190128

The Scientist In Vivo Pharmacology will support drug discovery of novel inhaled therapeutics for pulmonary arterial hypertension.   The position is a lab-based role in close partnership with CVM In Vivo Pharmacology and the successful candidate will have an expertise in pre-clinical inhaled delivery systems with a background in the cardiovascular disease area, an understanding of the pathophysiology of pulmonary arterial hypertension and the ability to manage their work independently.  The primary responsibility of the Scientist In Vivo Pharmacology is to provide scientific and technical support for conducting research involving in vivo inhaled preclinical studies with the goal of progressing novel drug candidates into clinical development and beyond. The qualified Scientist In Vivo Pharmacology needs to independently plan and execute in vivo experiments, to develop and follow protocols, to document data, to troubleshoot problems, and to interpret data and communicate results. Maintains state-of-the-art knowledge in the inhaled delivery area. Reviews and stays current on published literature. Responsibilities include scientific leadership, study planning, hands-on study execution, analysis, troubleshooting and documentation according to best business practices.
  • Ph.D., M.D., or M.D./Ph.D. with 8+ years of pharmaceutical experience or a M.S. with 15+ years of pharmaceutical experience and a focus on inhaled delivery in preclinical species.
  • Expertise in rodent inhaled capabilities with dry-powder and nebulized experience is required.
  • Experience evaluating pulmonary physiology (mechanics and function) and respiratory endpoints (plethysmography) is required.
  • Experience with setting up inhaled delivery systems and evaluating novel pre-clinical inhaled delivery systems.
  • Demonstrated skills in performing pharmacological and mechanistic studies in models of cardiovascular diseases is required.
  • Demonstrated skills in cardiovascular basic research is required.
  • Working knowledge of pharmacology and/or drug discovery principles is required.
  • Understanding of the overall process of drug discovery and development is preferred.
  • Pro-actively investigate, improve, change or adapt existing methods and techniques.
  • Working in cross-functional teams, including discovery, biomarkers and program project teams to shape a discovery and pharmacology strategy for novel drug candidates and will bring forward novel translational animal models and innovative technologies to support long-term plans.
  • Present scientific accomplishments internally and externally to the scientific community and discuss ideas with key opinion leaders.
  • Study planning, execution, troubleshooting, documentation according to best business practices.
  • Interprets and integrates data and makes recommendations for critical discovery project decisions and achievement of project goals.
  • Peer reviewed publication record in relevant fields is preferred.

Primary Location
United States-Pennsylvania-Spring House-
Janssen Research & Development, LLC. (6084)
Job Function
Requisition ID