Johnson & Johnson Careers

Principal Scientist, Bioinformatics

Spring House, Pennsylvania

Job Description

Requisition ID: 5517190128

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Principal Scientist, Bioinformatics located in Spring House, PA.
At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found. 
Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit for more information. 
We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it.
Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer.
As a member of the Biologics Discovery Group, the Bioinformatics Principal Scientist will work closely with cross-functional teams to provide computational biology support to the antibody discovery process.  This will include the application of structural analysis to sequences from both internal and public databases to enable protein design, CRISPR-based gene editing, and antibody repertoire analysis.  The identification of relevant isoforms and orthologous genes will be a critical responsibility to support immunization, pharmacology, and toxicology.                                                                                                                                                                                                           
Essential Functions:
  • Apply structural analysis to protein sequences to inform reagent design
  • Analyze gene isoform expression data and design guide RNAs for gene editing
  • Analyze antigen-dependent repertoires from immunization host species
  • Optimize signal peptide design

  • PhD in Computational Biology, Structural Biology, Bioinformatics or related field
  • Must have a minimum of 0-3 years of experience (Academia will be considered)
  • Familiarity with RNAseq data analysis

Primary Location
United States-Pennsylvania-Spring House-1400�McKean�Road
Janssen Research & Development, LLC. (6084)
Job Function
Requisition ID