Johnson & Johnson Careers
Spring House, Pennsylvania
Requisition ID: 5442190128
Janssen Research & Development, a member of the Pharmaceutical Companies of Johnson & Johnson, is recruiting for a Scientific Director, PK/PD Modeling and Simulation Group Head, located in Springhouse, PA.
At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal.
Janssen Research & Development, L.L.C. develops treatments that improve the health and lifestyles of people worldwide. Research and development areas encompass novel targets in neurologic disorders, gastroenterology, oncology, infectious disease, diabetes, hematology, metabolic disorders, immunologic disorders, and reproductive medicine. Responsibilities include:
You will play a leading role in driving preclinical Pharmacokinetic/ Pharmacodynamic (PK/PD) strategies and human dose predictions from early discovery to First in Human (FIH). The group leader will be expected to help identify key issues in early discovery and additionally pursue new opportunities with outside partners and thought leaders to develop next generation DMPK strategies and technologies (Advanced PK/PD Modeling and Simulation techniques).
You will collaborate with the therapeutic areas, acting as a point of contact between DMPK and other discovery (chemistry, biology, safety) and development colleagues to help guide the appropriate in vitro and in vivo ADME studies as well as the design of in vivo PK/PD studies needed using advanced modeling and simulation approaches with the goal of providing guidance for the human efficacious and starting dose for lead candidates in early discovery and development. Such approaches include (but will not be limited to) physiologically based pharmacokinetic (PBPK) approaches (Simcyp, Gastroplus and similar software), systems PK (Matlab, JDesigner, Simbiology and similar software) , and classical PK/PD approaches (Nonmem, Monolix, Winnonlin and similar software) to help (a) predict human PK profile (b) quantify the exposure / response relationship needed to quantify “efficacy” and to guide dose selection (c) help guide in vivo experimental design of both PK exposure studies as well as pharmacodynamic end points (d) help quantify and derisk any exposure related AE issues (e) help determine quantifiable in vitro in vivo extrapolation relationships across lead series.
PhD in Pharmacology or Engineering or Mathematics or Physics, and related fields with a specific focus on pharmacological modeling with a minimum of 12 years of relevant industry experience are required.
A strong understanding of DMPK principles and experience in supporting drug discovery are required.
Proven skills in modeling and simulation, supported by a publication track record is preferred.
Minimum of 3 years of managerial experience is preferred.
Excellent interpersonal, organizational, oral/written communication and teamwork skills are required.
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
United States-Pennsylvania-Spring House-1400�McKean�Road
Janssen Research & Development, LLC. (6084)