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Principal Scientist, Investigative Immunotoxicology
Requisition ID: 4870171114
Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is hiring a Principal Scientist, Investigative Immunotoxicology located in Spring House, PA.
At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found.
Janssen Biotech, Inc. delivers on the promise of new treatments and ways to improve the health of individuals with serious disease. Built upon a legacy of innovative firsts, Janssen Biotech pursues advancing patient care with immunology and oncology solutions. Please visit www.JanssenBiotech.com for more information.
We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it.
Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer.
The Principal Scientist in Investigative Immunotoxicology (ITT) will work with the Head of ITT to evaluate potential immune system-related risks associated with our biotherapeutic pipeline. The Principal Scientist will work with Project Toxicologists providing strategic and scientific input to multidisciplinary Project Teams - progressing biotherapeutics from discovery to first-in-human and beyond.
The Principal Scientist will design strategies to evaluate potential immunotoxicology risks and with the Project Toxicologist will conduct immunotoxicology based risk assessment. Strategies will include literature evaluation, as well as direct experimental approaches. The Principal scientist has responsibility for a lab based approach for evaluating immune system-related effects.
The Principal Scientist independently designs, conducts and leads studies to evaluate the effects of immunomodulatory compounds using various in vivo and in vitro model systems including, but not limited to, cytokine assessment, immune response, flow cytometry and functional cell based assays.
The Principal Scientist interacts with Contract Research Organizations (CROs) at multiple levels, including: transferring methods developed within ITT at Janssen, monitoring CRO validations, and the monitoring of immune endpoints during both GLP and non-GLP studies.
The Principal Scientist investigates and develops novel experimental methods/technologies, contributes to improvement of existing methods and develops new in vitro/in vivo models to enhance our understanding of potential immunotoxicology risk and translatability in clinic.
Conducts experiments and reports data following Data Integrity standards, and writes reports for regulatory submission. Participates in communication of information and data presentation in oral and written format both in-house and at appropriate external forums.
Responsible for the development of all employees within the department by supporting the development of Human Resources Planning (HRP) programs including management development and training to meet current and future business needs. Provide an environment, which encourages the company's commitment to equal employment opportunity and the value of a diverse work force. The Principal Scientist, Investigative Immunotoxicology will:
- Provide Immunotoxicology expertise at all stages of biologic discovery and development for all biologics programs
- Design and monitors experiments conducted at CROs
- Provide strategic and technical leadership to the organization on scientific and management matters
- Develop in vitro and in vivo models of immune-related effects with the goal of translatability
- Maintain an industry leading expertise in Immunotoxicology as it related to biologic therapeutics
- Represent the organization to senior management and peer groups within Janssen and Johnson & Johnson
- Maintain strong scientific network in academia and the pharmaceutical/ biotechnology industry to enable external interactions, consulting and recruiting
- Be a mentor/coach to key scientific staff and guide/enable their career/professional development
- Ph.D., in immunology, immunotoxicology, toxicology or related discipline with at least 5 years of relevant experience OR a M.S., in immunology, immunotoxicology, toxicology or related discipline with at least 8 years of relevant experience OR a professional degree (DVM, VMD) with training or extensive experience in immunotoxicology, immunology or related biologic disciplines is required
- A minimum of 5 years of pharmaceutical/biotechnology research management or related experience in drug development with deep expertise in immunological techniques is required
- Extensive experience with flow cytometry and immunoassays is required
- Demonstrated understanding of the Good Laboratory Practices (GLP) is required
- Knowledge of Health Authority regulations and guidelines for the development of biologics (e.g. ICH, FDA, EMEA, PMDA) is preferred
- Established expertise in Immunotoxicology is required
- This role requires excellent communication, interpersonal skills, a high level of organizational ability and attention to detail
United States-Pennsylvania-Spring House
Janssen Research & Development, LLC. (6084)