Johnson & Johnson Careers

Principal Scientist, Mechanistic & Investigative Toxicology

Spring House, Pennsylvania

Job Description

Requisition ID: 4757180301

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Principal Scientist, located in Spring House, PA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found.  

Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit for more information.  

We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it.

Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer.

We are seeking a motivated and independent individual for a Principal Scientist position in the Mechanistic & Investigative Toxicology (MIT) Group within Preclinical Development & Safety (PD&S). The individual will have strong critical thinking skills and a demonstrated track record for problem solving. The candidate will work in a collaborative team environment within PD&S and Therapeutic Areas where she/he will provide support to discovery teams as well as engage in core activities within the MIT group. Project and MIT responsibilities include:

  • Proactive risk assessment of potential target and chemotype-related toxicity issues, which will include providing target assessments, preparing safety strategies, evaluating the competitive landscape, and designing/implementing in vitro and in vivo studies to drive toxicology plans
  • Participate in issue-resolution teams, where she/he will be required to contribute to hypotheses generation and drive the science for toxicology issue resolution in drug discovery and development. 
  • Participate in external collaborations with industry and/or academia and actively identify new technologies with potential for de-risking potential toxicology liabilities
  • Drive internal or external characterization of value-added in vitro/in vivo models or biomarkers for toxicity assessment
  • Contribute towards and lead MIT scientific strategies
  • Closely interact with scientists in other functional areas including pathologists, clinical pathologist, study directors, and development project leaders in the US or Belgium

  • PhD is required, a PhD within the field of Pharmacology, Toxicology, Physiology, or Pharmaceutical Sciences is preferred
  • Postdoctoral experience is required
  • At least 4 years of work experience, after a postdoc, in investigative toxicology or related field is required
  • Demonstrated competence in solving toxicity issues from diverse organ systems is required
  • Broad technical expertise in cell & molecular biology or biochemistry is preferred
  • Experience with in vitro or in vivo model development for issue resolution is preferred
  • Demonstrated competence for project and/or team leadership is preferred
  • A background in safety biomarkers is preferred
  • Travel up to 10% both domestic and internationally is required

Primary Location
United States-Pennsylvania-Spring House
Janssen Research & Development, LLC. (6084)
Job Function
Requisition ID