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Senior Principal Scientist Biomarkers, Metabolic Complications, Cardiovascular & Metabolism Discovery
Requisition ID: 4203180222
Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for an Senior Principal Scientist, located in Boston, MA.
At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found.
Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit http://www.janssenrnd.com/ for more information.
We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it.
Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer.
The Senior Principal Scientist within our Biomarker CVM Discovery group will support drug discovery of novel therapeutics for cardiovascular, fatty liver and/or chronic kidney diseases. The Sr. Prin. Sci. applies current biomarker technologies and statistical approaches to provide strategy, assay selection, development, validation, execution and analysis of target engagement markers, proximal pharmacodynamics markers, patient stratification biomarkers, markers of disease progression and response to therapy for cardiovascular and metabolic disease programs and states. He/she works closely with colleagues from discovery and clinical groups, quantitative pharmacometrics and statistics to develop Biomarker plans to support robust decision-making in the early clinical space. Additional responsibilities include:
Ensure effective cross functional interactions and collaborations across the different functional areas that relate to Biomarker discovery, development and execution, and directs and oversees the outsourcing and validation of clinically applicable biomarker assays, manages budgets and internal and external contracts related to Biomarker development activities
Provide guidance on the efficient and effective use of more traditional soluble biomarkers as well as “omic” approaches to advance the understanding and development of agents to treat/predict disease with experience in the application and analysis of genetic, genomic, proteomic and metabolomic data
Ph.D. degree in biomedical science with at least 8 years of relevant biomarker or translational research experience in an industry setting is required
Proven record on publication of biomarker data in high-quality scientific, technical or medical journals is required
Previous experience in Cardiovascular & Metabolism biomarkers or other Therapeutic Areas is preferred
Experience in leading a research/biomarker team, motivating and influencing people is required
In-depth understanding of the research laboratory environment; familiarity with all basic and some complex laboratory equipment / instrumentation is required
Demonstrated ability to work on assay development in a laboratory setting, and generate and accurately document data is required
Willingness to spend 25 – 50% time at the bench is required
Understanding of the overall process of drug discovery and development is required
Experience with clinical diagnostics and their uses is preferred
Extensive experience with clinical sample handling is preferred
Prior experience in working with external companies and alliance partners, and in managing successful research collaborations is required
This position may require 10% travel.
Janssen Research & Development, LLC. (6084)