Johnson & Johnson Careers

Scientist Cell Biology Assay Development

Spring House, Pennsylvania
R&D


Job Description

Requisition ID: 3824190503

Janssen Research & Development, LLC., a member of the J&J Family of Companies, is recruiting for a Scientist, Cell Biology Assay Development in Spring House, PA as part of a strategic build in lead identification and high-throughput screening (HTS).


At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science.

 

We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal.  Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

 

The Screening department within Lead Discovery is growing with both new positions and capital investment. The department is responsible for the delivery of small-molecule qualified hits for the initiation of hit-to-lead programs within the Therapeutic Areas. Major activities include assay development, screening, and pharmacological profiling. The Screening Team collaborates closely with Janssen Therapeutic Areas and functional teams, the Innovation Centers, and external collaborators in academia and industry. We seek individuals with a strong ability to connect key stake holders for the delivery of goals and objectives, fostering an environment of collaboration, collegiality and positive communication, and who show superior performance in the context of a multidisciplinary, geographically disperse team.


In this exciting role, you will:
  • Learn and apply early drug discovery approaches in a multidisciplinary team environment.
  • Develop innovative cell-based approaches to screening and hit triage using high-content imaging, high-throughput flow cytometry, 3D cell culture and co-culture methods.
  • Develop strategies to characterize hits and identify novel targets from phenotypic screens, using techniques such as phosphoprotein profiling, gene expression profiling and genetic manipulation.
  • Collaborate extensively with program teams and computational colleagues to analyze different types of assay data, and identify the most promising compounds in early Hit-to-Lead programs.
  • Analyze data and present results at program team meetings.
  • Attend and present data at in-house seminars and external scientific conferences.
  • Publish research in high-quality journals, as appropriate.

Qualifications
  • A Ph.D in biochemistry, cell biology, pharmacology or related fields is required.
  • A minimum of 2 years of postdoctoral experience in biochemistry, cell biology, pharmacology or related fields is required.
  • Experience using high content imaging and/or flow cytometry is required.
  • A demonstrated ability to apply novel approaches to understand biological pathways, as evidenced through strong peer-reviewed publications, is required.
  • Significant experience using state-of-the-art cell-based assay development techniques is required.
  • Familiarity with CAS/CRISPR and RNAi approaches is preferred.
  • Experience with protein and gene expression profiling is preferred.
  • Excellent written communication, verbal communication, and oral presentation skills are required.
  • Experience in cardiovascular, immunology, infectious diseases, neuroscience and/or oncology therapeutic areas is preferred.
  • Experience working with and/or guiding external collaborators in industry or academia is preferred.
  • This role is based in Spring House, PA and may require up to 10% of domestic and international travel.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.



Primary Location
United States-Pennsylvania-Spring House-
Organization
Janssen Research & Development, LLC. (6084)
Job Function
R&D
Requisition ID
3824190503