Johnson & Johnson Careers

Scientist, MALDI Imaging Mass Spectrometry

Spring House, Pennsylvania

Job Description

Requisition ID: 3002190821

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Scientist, MALDI Imaging Mass Spectrometry located in Spring House, PA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at and follow us @JanssenGlobal.  Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.


This is a technical leadership position within the Biophysics group of the Biologics Development Sciences (BDS) Department, which is accountable to project teams and management for the quality, appropriateness, and scientific rigor of experimental data. The Biophysics group is responsible for characterizing and analyzing large molecule biotherapeutic drug candidates pertaining to all Janssen’s Therapeutic Areas, from early discovery through NME declaration.

Within Biophysics, the Target Discovery and Molecular Tools QC team is responsible for supporting target identification and validation studies in various tissues.  The group also ensures that all tool protein reagents are well-behaved from a biophysical perspective.  

The Scientist will focus on using MALDI-IMS to assess tissue distribution of target isoforms and post-translational modifications of targets in healthy and diseased tissues.  This scientist will be responsible for cross-training other scientists in the MALDI-IMS technology to expand our group capabilities so that there is technical redundancy for this highly critical workflow. This scientist will be a subject matter expert for Janssen on the design of MALDI-IMS studies, as well as the interpretation of imaging data.  These datasets may be used in patent filings to support our therapeutic intellectual property.  This individual’s effort will directly support portfolio advancement and lead selection based on the criteria outlined in a Target Molecule Profile put in place by Janssen Biotherapeutics and the requirement outlined by the Therapeutic Areas to achieve the therapeutic needs of the program.  Biophysical research studies will focus mainly in the early target validation and discovery phase.

Essential Functions:

  1. Provide expertise in MALDI-IMS techniques to be applied to all therapeutic targets. 

  2. Collaborate with other team members on Biophysics or JBIO development initiates.

  3. Maintain a laboratory notebook in compliance with Good Laboratory Practices (GLP).

  4. Author technical reports to support NME and IND filings.

  5. Communicate results to other scientific staff members and project leaders in the form of written and oral communications.

  6. Continue to enhance MALDI-IMS and other mass spectrometric technology in the laboratory to keep up with the latest developments in the field.

  7. Develop new methods/techniques to be used in supporting goals and objectives within JBIO. 

  • Education: M.S. with at least 7 years of scientific experience in the pharmaceutical/biotechnology industry or PhD with 0-3 years of industry experience
  • Expertise in mass spectrometry required
  • Expertise in MALDI-IMS is required
  • Expertise in HPLC separations, proteomics, and/or informatics is a plus. 
  • Strong collaborative skills and the ability to work in a team environment.


Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability

Primary Location
United States-Pennsylvania-Spring House-Welsh & McKean Roads
Janssen Research & Development, LLC (6084)
Job Function
Requisition ID