Johnson & Johnson Careers

Associate Scientific Director, Biophysics

Spring House, Pennsylvania

Job Description

Requisition ID: 2465180920

Janssen Research and Development, L.L.C., a member of Johnson and Johnson's Family of Companies, is recruiting for an Associate Scientific Director located in Spring House, PA.


At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found. 


Janssen Biotech, Inc. delivers on the promise of new treatments and ways to improve the health of individuals with serious disease. Built upon a legacy of innovative firsts, Janssen Biotech pursues advancing patient care with immunology and oncology solutions. Please visit for more information.


We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it.

The Associate Scientific Director in Biophysics will have strong scientific, managerial, and leadership skills suited for an entrepreneurial environment. They will develop, lead, and manage new methods and techniques and employ established biophysical methods to characterize the quality of bispecific monoclonal antibodies and other therapeutic biologics for in vivo use that meet the target molecular profile for a given therapeutic indication. One key objective for this position is to use biophysics to predict and determine the quality of monoclonal antibodies in addition to next generation biologics like multi-specific antibodies and CAR-T cells.


The Biophysics Group within Janssen Biotherapeutics (JBIO) develops and employs methods to assess biophysical characteristics of biotherapeutics such as binding affinity, solubility, intact primary structure and molecular stability, post-translational modification risks, concentratability, blood/serum compatibility, thermal/chemical/pH stress, purifiability, aggregation potential, intact molecular weight determination, peptide mapping, and post-translational modifications by mass spectrometry.


The Associate Scientific Director will ensure that methods used are state of the art and optimal for testing pipeline assets. This position will be responsible for a team that is charged with the characterization of multi-specific biologics from Lead Generation that continues through Lead Optimization and Protein Expression, culminating in the final determination of the biophysical and structural quality of clinical candidates entering the development portfolio. The Associate Scientific Director is expected to have the scientific depth and vision to lead a team in the design, conduct, and analysis of the results of experiments intended to characterize therapeutic proteins in terms of various biophysical techniques such as dynamic light scattering, static light scattering, calorimetry, surface plasmon resonance, analytical ultracentrifugation, mass spectrometry, chromatography and other methods.

The Associate Scientific Director will contribute to other business critical initiatives such as serving as a project leader for therapeutic programs within JBIO and participating in the development of new therapeutic concepts.



  • Knowledge of a broad array of biophysical methods and techniques utilized to characterize next generation biologics including multi-specific antibodies and other therapeutic proteins using biophysical techniques
  • Function as a JBIO Team Leader
  • Lead and supervise experimental approaches for elucidating key biophysical properties to assure high quality biologics are developed
  • Communicate strategy and results to program teams and management
  • Mentor and develop junior group members in their scientific and professional development


Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Primary Location
United States-Pennsylvania-Spring House
Janssen Research & Development, LLC. (6084)
Job Function
Requisition ID