Associate Scientist, Oncology In Vivo
Location: Beerse, Belgium
The Associate Scientist will join the Oncology in vivo group efforts in the characterization and development of small molecules and biologics including those that function as immune modulators for the treatment of cancer. They may also characterize new cell therapies such as CAR-Ts. They will be responsible for contributing to the ex vivo and in vivo studies for programs across the different stages of pre-clinical drug discovery. Their responsibilities include the design and execution of in vivo studies for the validation and characterization of targets or therapeutic agents in the area of oncology and tumor immunology. Specifically, the candidate will establish and perform in vivo model development, target inhibition, efficacy, mechanism of action, and pharmacokinetic/pharmacodynamics (PK/PD) biomarker studies, and will evaluate the influence of dose, schedule and therapeutic combinations in various cancer models.
•Assist with design, execution, interpretation and reporting for standard in vivo preclinical cancer models.
•Conduct methods of in in vivo experimentation, including tumor implantation, dosing, proper handling of chemotherapeutics, tumor measurement, health monitoring, and data collection and analyses.
•May establish and perform in vivo model development.
•May perform bioluminescent imaging studies using molecular reporters or disseminated/ metastatic disease models.
•May assist to analyze data using appropriate statistical methods and preparing data for presentation-ready format.
•Some weekend, evening, and holiday dosing/ animal monitoring required.
•A minimum of a Bachelor’s or Master’s degree in Life Sciences (such as Biology, Biochemistry, Pharmacology, Tumor Immunology) is required with at least 1 year of relevant pharmaceutical or biotech industry/ lab/ academic experience is required.
•Experience with the cell culture of cancer or immune cells is preferred.
•Experience with an oncology-relevant rodent model such as xenografts, syngeneic models, primary grafts, orthotopic models, transgenics or genetically engineered tumor models is preferred.
•Experience with small molecules and/ or biologics is preferred.
•Strong organizational skills including excellent record keeping skills are essential.
•Experience with the adherence to animal welfare and compliance regulations is required.
•Must have excellent verbal and written communication skills.
•Must have excellent interpersonal skills, with the ability to interact effectively with people.
•This position will require occasional weekend, evening, and holiday dosing/animal monitoring.
•Verbal and written fluency in English
•Hiring will be contingent upon completion of laboratory animal research training courses accredited by the Federation of Laboratory Animal Science Associations (FELASA category B or C) or similar foreign certification.
Janssen Pharmaceutica N.V. (7555)