Senior Associate Scientist, Oncology In Vivo - – Bladder Cancer
Location: Beerse, Belgium
The Senior Associate Scientist will join the Oncology in vivo group efforts in the characterization and development of small molecules and biologics including those that function as immune modulators for the treatment of bladder cancer. They may also characterize new cell therapies such as CAR-Ts. They will be responsible for contributing to the ex vivo and in vivo studies for multiple research programs across the different stages of pre-clinical bladder cancer research programs. Their responsibilities include the design, execution and interpretation of in vivo studies for the validation and characterization of targets or therapeutic agents in the area of oncology and tumor immunology. Specifically, the candidate will establish and perform in vivo bladder orthotopic model development, target inhibition, efficacy, mechanism of action, and pharmacokinetic/pharmacodynamics (PK/PD) biomarker studies, and will evaluate the influence of dose, schedule and therapeutic combinations in bladder cancer models.
•Independently design, perform, interpret and report standard in vivo preclinical cancer models.
•Conduct methods of in in vivo experimentation, including tumor implantation, dosing, proper handling of chemotherapeutics, tumor measurement, health monitoring, and data collection and analyses.
•May establish and perform in vivo model development, including the improvement, adaptation, or change to existing research methods.
•May contribute to ex vivo analysis of tumor cells or immune cells by FACS, IHC or ELISA, RT-PCR, or Luminex®.
•May perform bioluminescent imaging studies using molecular reporters or disseminated/ metastatic disease models.
•Analyze using appropriate statistical methods and present data in a clear presentation-ready format.
•Manage multiple in vivo experiments or projects simultaneously.
•Contribute on various projects outside of their own, collaborate with partners from all relevant functions, and keep up-to-date in the literature related to their field.
•Act as a resource on project teams with clear and professional verbal and written communication
•Some weekend, evening, and holiday dosing/ animal monitoring required.
•A minimum of a Bachelor’s degree in Life Sciences (such as Biology, Biochemistry, Pharmacology, Tumor Immunology) is required with at least 6 years of relevant pharmaceutical or biotech industry/ lab/ academic experience OR a Master’s degree (M.S.) with at least 3 years of relevant pharmaceutical or biotech industry/ lab/ academic experience is required.
•Experience with the cell culture of cancer or immune cells is preferred.
•Experience with relevant bladder cancer rodent models including orthotopic models is required.
•Experience with xenografts, syngeneic models, primary grafts, orthotopic models, transgenics or genetically engineered tumor models is preferred.
•Experience with small molecules and/ or biologics is preferred.
•Experience with immune-modulatory agents, vaccines or cell therapies such as CAR-Ts is preferred.
•Experience with tumor implantation techniques and dosing, proper handling of therapeutics, tumor measurement, health monitoring, and data collection and analysis required.
•Experience with bioluminescent imaging, flow cytometry, IHC, ELISA, RT-PCR, Westerns, or Luminex® is preferred.
•Strong organizational skills including the ability to manage several projects simultaneously; detail oriented with excellent record keeping skills are preferred.
•Experience with the adherence to animal welfare and compliance regulations is required.
•Must have excellent verbal and written communication skills.
•Must have excellent interpersonal skills, with the ability to interact effectively with people.
•Must have strong organizational, data management, and record-keeping skills.
•The ability to manage several projects simultaneously is preferred.
•The ability to effectively present scientific data and concepts to colleagues and teams is required.
-This position will require occasional weekend, evening, and holiday dosing/animal monitoring.
•Verbal and written fluency in English
•Hiring will be contingent upon completion of laboratory animal research training courses accredited by the Federation of Laboratory Animal Science Associations (FELASA category B or C) or similar foreign certification, either prior to, or within 6 months of hire.
Janssen Pharmaceutica N.V. (7555)