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Sr. Associate Scientist - Oncology In Vivo

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Job Description


Associate Scientist, Oncology In Vivo 

Location:  Beerse, Belgium 

The Associate Scientist will join the Oncology in vivo group efforts in the characterization and development of small molecules and biologics including those that function as immune modulators for the treatment of cancer. They may also characterize new cell therapies such as CAR-Ts. They will be responsible for contributing to the ex vivo and in vivo studies for programs across the different stages of pre-clinical drug discovery. Their responsibilities include the design and execution of in vivo studies for the validation and characterization of targets or therapeutic agents in the area of oncology and tumor immunology. Specifically, the candidate will establish and perform in vivo model development, target inhibition, efficacy, mechanism of action, and pharmacokinetic/pharmacodynamics (PK/PD) biomarker studies, and will evaluate the influence of dose, schedule and therapeutic combinations in various cancer models.

Principal Responsibilities

•Assist with design, execution, interpretation and reporting for standard in vivo preclinical cancer models.
•Conduct methods of in in vivo experimentation, including tumor implantation, dosing, proper handling of chemotherapeutics, tumor measurement, health monitoring, and data collection and analyses.
•May establish and perform in vivo model development.
•May perform bioluminescent imaging studies using molecular reporters or disseminated/ metastatic disease models.
•May assist to analyze data using appropriate statistical methods and preparing data for presentation-ready format.
•Some weekend, evening, and holiday dosing/ animal monitoring required.



Qualifications
Qualifications

•A minimum of a Bachelor’s degree in Life Sciences (such as Biology, Biochemistry, Pharmacology, Tumor Immunology) is required with at least 6 years of relevant pharmaceutical or biotech industry/ lab/ academic experience OR a Master’s degree (M.S.) with at least 3 years of relevant pharmaceutical or biotech industry/ lab/ academic experience is required.
•Experience with the cell culture of cancer or immune cells is preferred.
•Experience with an oncology-relevant rodent model such as xenografts, syngeneic models, primary grafts, orthotopic models, transgenics or genetically engineered tumor models is required.
•Experience with small molecules and/ or biologics is required.
•Experience with immune-modulatory agents, vaccines or cell therapies such as CAR-Ts is preferred.
•Experience with tumor implantation techniques and dosing, proper handling of therapeutics, tumor measurement, health monitoring, and data collection and analysis required.
•Experience with bioluminescent imaging, flow cytometry, IHC, ELISA, RT-PCR, Westerns, or Luminex® is preferred.
•Strong organizational skills including the ability to manage several projects simultaneously; detail oriented with excellent record keeping skills are preferred.
•Experience with the adherence to animal welfare and compliance regulations is required.
•Must have excellent verbal and written communication skills.
•Must have excellent interpersonal skills, with the ability to interact effectively with people.
•Must have strong organizational, data management, and record-keeping skills.
•The ability to manage several projects simultaneously is preferred.
•The ability to effectively present scientific data and concepts to colleagues and teams is required.
•This position will require occasional weekend, evening, and holiday dosing/animal monitoring.

Other Requirements

•Verbal and written fluency in English
•Hiring will be contingent upon completion of laboratory animal research training courses accredited by the Federation of Laboratory Animal Science Associations (FELASA category B or C) or similar foreign certification.



Primary Location
Belgium-Antwerp-Beerse-
Organization
Janssen Pharmaceutica N.V. (7555)
Job Function
R&D
Requisition ID
2005802261W