Post-doctoral Scientist position (3 years) for our in vitro lab in the Global Safety Pharmacology team.
‘Caring for the world, one person at a time’... inspires and unites the people of Johnson & Johnson. We embrace research and science - bringing innovative ideas, products and services to advance the health and well-being of people.
Employees of the Johnson & Johnson Family of Companies work with partners in health care to touch the lives of over a billion people every day, throughout the world.
Janssen Research & Development develops treatments that improve the health and lifestyles of people worldwide. R&D development areas encompass novel targets in neurologic disorders, gastroenterology, oncology, infectious disease, diabetes, hematology, metabolic disorders, immunologic disorders, and reproductive medicine.
Janssen Research & Development, a division of Janssen Pharmaceutica NV, has opened up a stimulating post-doctoral research opportunity at its site in Beerse, Belgium. We are seeking a highly motivated, independent and passionate post-doctoral researcher to join our multinational Global Safety Pharmacology research group to work on a large European project (EIT health).
Global Safety Pharmacology is an expert center that supports our therapeutic areas across the globe with advice, safety testing and research from discovery, through clinical development and up to marketed product. The lab focuses on the safety pharmacology assessment of new chemical entities on vital organ systems, such as the heart, lungs and brain, using a range of preclinical models and starting in vitro.
The post-doctoral position will work in a European consortium, EIT health, to investigate drug induced cardiac and neuronal toxicities further advancing the currently used human induced pluripotent stem cell lines and develop second generation in vitro assays that can help to select safer drugs that ultimately will go the market.
For this role we are seeking an experienced PhD with excellent in vitro skills to advance small molecule drug safety programs toward the clinic. The successful candidate should be a well-organized, team-orientated, and have the ability to work autonomously. She/he should have good communication skills and will be trained to execute experiments.
Key job responsibilities:
• The candidate will develop assays using human induced pluripotent stem cells to recapitulate organ-specific toxicities (cardiac and neuronal).
• Research into better understanding adverse events found during safety screening.
• Understand the off- or on-target mechanisms of action and in vitro to in vivo translational relevance of models.
• The successful candidate will also have the possibility to work in close collaboration with in vivo cardiac and neuronal expert scientists within Janssen
Education & experience
• A Post-doc / PhD degree in biochemistry, pharmaceutical sciences or related fields with 1 - 3 years of experience
• Experience in electrophysiology methods (microelectrode arrays, calcium imaging, impedance, patch-clamp)
• Experience with induced pluripotent stem cells is an advantage
• Technical cell-lab skill and motivation to generate data / run studies
• Very strong communication and reporting skills
• Ability to present his/her work in internal as well as external meetings
• Able to work effectively in a team, particularly in order to facilitate the efficient generation of lab results
• Capable of producing high quality data which can translate into biologically meaningful information, ensuring data integrity
Janssen Pharmaceutica N.V. (7555)