Johnson & Johnson Careers
POSTDOCTORAL RESEARCH FELLOW: DEVELOPMENT OF BEST-IN-CLASS CAR-T CONSTRUCTS EXPLORING SIGNALNG DOMAINS AND T CELL ACTIVATION
Requisition ID: 1930190104
Caring for the world, one person at a time has inspired and united the people of Johnson & Johnson for over 130 years. We embrace research and science -- bringing innovative ideas, products and services to advance the health and well-being of people.
With $76.5 billion in 2017 sales, Johnson & Johnson is the world's most comprehensive and broadly-based manufacturer of health care products, as well as a provider of related services, for the consumer, pharmaceutical, and medical devices markets. There are more than 250 Johnson & Johnson operating companies employing over 125,000 people and with products touching the lives of over a billion people every day, throughout the world. If you have the talent and desire to touch the world, Johnson & Johnson has the career opportunities to help make it happen.
Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Janssen BioTherapeutics is searching for an energetic, highly-motivated Postdoctoral Fellow to drive the development of next-generation, solid tumor-based CAR-T therapies. Progress has been achieved targeting hematological malignancies with gene-edited T cells in the clinic; however, the efficacy of these targeted cell therapies in solid tumors remains marginal, leaving many unanswered questions. This postdoctoral fellow position will provide a rare opportunity to execute cutting-edge, bench-to-bedside research with the intent of delivering novel CAR-T therapeutics for solid tumor patients. The Research Fellow will partner throughout the Janssen R&D organization and participate in cross-functional team discussions, where the successful candidate will explore strategies to optimize the signaling domains of CAR constructs that lead to efficient signaling for T cell activation. Responsibilities will include determining the right signaling domains to incorporate in the CAR-T construct, exploring the interplay between endogenous TCRs and CAR constructs to improve the selective targeting of tumor tissue, and investigating the ability of bispecific CARs to deliver split-signals for T cell activation. Upon completion of the postdoctoral program, the Fellow will have acquired valuable career experience that enables entry into translational academic settings, biotech-related opportunities, and/or continued development in large pharma.
Suitable candidates will have a recent PhD in immunology, immuno-oncology, or a related field. Research experience in one or more of the following areas is preferred:
- Strong background in T cell signaling, TCR and CAR-T’s mechanism of action
- Hands on experience in tumor cell biology, T cell activation studies and basic T cell assay development
- Research background in oncology and immunology
- Must be able to work in US permanently
Candidates must display an ability to independently design and execute research. In addition to a broad knowledge of immunology and oncology, we are seeking an individual with deep intellectual curiosity, and excellent communication and interpersonal skills
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
United States-Pennsylvania-Spring House-
Janssen Research & Development, LLC (6084)