Principal Scientist/Associate Director, IDerm

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Job Description

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Principal Scientist/Associate Director in Translational Science & Biomarkers Immunology, located in La Jolla, CA.

At Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found.
Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit for more information.

We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it.

Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer.

The Translational Science Immunology team at Janssen R&D located in La Jolla, California is seeking a highly motivated Principal Scientist/Associate Director level translational scientist. The successful candidate will join the Translational Science team to help develop cutting-edge therapeutics for the treatment of autoimmune diseases, with specific focus on Dermatological indications. Extensive background in autoimmune/ inflammatory diseases and the drug development process is required.
In partnership with Discovery, Translational Medicine, Clinical Development, and other functions, the Translational Science Program Lead (TSPL) will be responsible for crafting and implementing the Translational Science and Biomarkers strategy for programs entering clinical trials. The TS program lead will also be responsible for the evaluation and generation of translational data package(s) to inform disease positioning for an asset(s) as they prepare to enter clinical development. Working closely with wet lab and data scientists within the TS team, other functions and with CROs, as appropriate, she/he will ensure the development of stage-appropriate, fit-for-purpose target engagement/occupancy and PD assays for FIH and beyond. The TSPL will lead implementation of the TS strategy for a program and support the program as it advances through development. The successful candidate will have a strong oral and written communication skills, be able to work with limited supervision/high level of autonomy and effectively collaborate with and/or supervise associates within the group and partner effectively with data scientists within the team.

Responsibilities include:
• Build the scientific rationale for disease positioning for asset(s) as they reach LO/LLO.
• Identify gaps in knowledge or understanding in the target/pathway and design strategic steps to fill those gaps and leverage TS/other functions to do so by working effectively in a matrix environment
• Identify and ensure the development and validation of immunoassays and PD readouts for specific programs entering FIH/early development.
• Execute research activities with high level of autonomy, provide critical analysis/interpretation of data, report/communicate results and participate in scientific discussions.
• Supervise/manage a member(s) within the team in order to deliver project goals and objectives.
• Work effectively with data scientists to identify and drive molecular-data based PD assays.

• PhD and/or MD with > 6 years of experience in immunology or related field in Industry is required.
• Proven track record of scientific contributions including peer reviewed publications and presentations is required.
• Experience with the development, qualification, validation of immunoassays is required.
• Previous experience with working in a cross-functional team to transitioning candidate molecules from Discovery to FIH/POC studies is preferred.
• Proficiency with designing and analyzing multicolor flow cytometry/FACS-based and/or CyTOF assays is preferred.
• Experience with some or all of the following molecular biology techniques/platforms: DNA/RNA/protein extraction, QPCR, NanoString, RNAseq and ELISA/MSD/Luminex/Singulex is required. Functional assays including proliferation, Treg functional assays, CTL killing assays is preferred.
• Prior supervisory experience is preferred.
• Travel requirement <10% annually.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.


Primary Location
United States-California-San Diego-
Janssen Research & Development, LLC (6084)
Job Function
Requisition ID