Johnson & Johnson Careers

Director / Senior Director, Discovery Chemistry

Beerse, Belgium

Job Description

Requisition ID: 1905740270W

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Director/Senior Director, Discovery Chemistry, for our site in Beerse, Belgium.
At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found.  
Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit for more information.  
We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it.
Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer.
The newly formed Global Discovery Chemistry organization within Discovery Sciences is committed to the delivery of high-quality drug candidates working with all six Janssen Therapeutic Areas (TA) discovery teams.  This mission requires deep scientific expertise in a number of disciplines including chemistry, cellular and molecular pharmacology, enzymology, and screening technologies coupled with an ability to work collaboratively with internal and external partners.  Building on a strong legacy of success, we are currently seeking an outstanding individual to join our team as Director or Senior Director, Discovery Chemistry.  This position will be based at our campus in Beerse, near Antwerp Belgium.
This position will require the candidate to possess and leverage deep knowledge and capabilities to deliver differentiated clinical candidates to the Janssen product development pipeline within our Disease and Pathway Area Stronghold (DAS and PAS) strategy.  Using a mix of internal and external resources, this Director level role will partner with key stakeholders in the Therapeutic Areas and other internal groups, represent medicinal chemistry and lead cross-functional project teams, and be co-responsible for building, managing, and delivering high quality clinical molecules. Responsibilities of the Director / Senior Director will include:
  • Providing direct line leadership to a significant group of medicinal chemists and be accountable for coaching and developing the local talent base within the regional discovery chemistry organization
  • As a member of the regional discovery chemistry leadership team, this role will influence and implement strategy across global chemistry and contribute to the scientific direction of the regional discovery chemistry organization
  • Contribute to managing and delivering the portfolio across multiple therapy areas and together with other members of the regional leadership team help with portfolio prioritization and actively critique project progression
  • As a project leader, drive and direct medicinal chemistry functions within discovery projects, working in concert with partners in molecular and cellular biology, pharmacology, computational chemistry, ADME, structural biology, chemical development, and other relevant functions
  • Work with key CRO partners to develop the relationship between the partner and Janssen to ensure efficient support for project  
  • Participate in portfolio and stage-gate reviews, lead the preparation and presentation of dossiers for clinical candidate nomination and compound advancement
  • Help lead shaping and implementing strategies that support medicinal chemistry growth objectives at Janssen
  • Serve as a scientific expert in medicinal chemistry with both internal and external partners and provide recommendations regarding new targets and emerging external opportunities.
  • Provide chemistry drug discovery insights and objective assessment(s) to various stakeholders including colleagues in Discovery Sciences, the J&J Innovation Centers, and across multiple Therapeutic Areas.
  • In collaboration with key contacts within the therapy areas, identify opportunities for new projects to enter the portfolio
  • Ensure optimal interaction/communication and provide updates on project status to Discovery Chemistry & TA leadership

  • A minimum of 12 years’ experience in the biopharmaceutical industry with a proven track record of leading innovative drug discovery projects and providing key contributions to deliver clinical drug candidates is required
  • Direct experience of leading significant medicinal chemistry teams is required
  • Broad experience and proven accomplishments in medicinal chemistry, with significant experience of leading and delivering discovery programs from portfolio entry through to the delivery of a clinical candidate
  • Expert knowledge of modern methods of synthetic and medicinal chemistry with ability to successfully and simultaneously conduct medicinal chemistry on multiple projects is required
  • Solid understanding of cellular/molecular biology, biochemistry, disease pharmacology, mechanisms of drug metabolism and molecular toxicology, pharmaco-kinetic and pharmaco-dynamic sciences, and formulations for the in vivo evaluation of drug candidates is required
  • Experience with computational chemistry methods and biophysical techniques such as X-ray crystallography and macromolecular NMR is required
  • Ability to integrate multiple R&D disciplines into a successful strategic project plan is required
  • Experience in managing project budgets, aligning actions with overall strategy, and supporting business cases for decision-making is preferred
  • Strong track record of scientific contributions including peer reviewed first-author publications, patent applications, and presentations at major national meetings is required
  • Broad experience in the assessment of molecules identified from divergent small molecule screening campaigns with an ability to design and oversee execution of rational triage strategies to deliver tractable chemical leads to discovery teams
  • An unparalleled ability to interact collegially with biology leaders and their discovery teams to set the strategic direction for TA portfolios to drive early discovery programs to critical decision points
  • Strategic awareness and experience of leading and building new capabilities within the function is preferred
  • Up to 10% travel both domestically and internationally is required

Primary Location
Janssen Pharmaceutica N.V. (7555)
Job Function
Requisition ID