Johnson & Johnson Careers

Post Doc tracer metabolomics

Beerse, Belgium
Pharmacokinetics


Job Description

Requisition ID: 1805642850W

The Pharmacokinetics, Dynamics and Metabolism department of Discovery Sciences serves the various Therapeutic Area’s with ‘state-of-the-art’ analytical support in e.g. PK/PD studies, biomarker evaluation, ‘mode-of-action’ research, target binding/confirmation essay’s and conjugate analysis to support the discovery and development of (mainly) novel small molecule therapies. The department integrates metabolomics technologies in the existing High Throughput and (semi-)quantitative workflows to accelerate drug discovery and development. To support the on-going efforts to further elucidate & understand molecular mechanisms in disease, we like to strengthen our team with a

 
Post-Doc (2 yr’s) tracer metabolomics (m/f)
 
  • Develop/optimize novel UPLC-MS/MS and UPLC-HR-MS methods for the analysis of selected endogenous metabolites from cellular systems, biofluids and tissue in relation to organ functionality.
  • In collaboration with our academic partners optimize isotope deconvolution packages for rapid and accurate analysis of incorporation of stable isotopic labels in target metabolites
  • Design tracer ‘feeding’ experiments in collaboration with our in-vitro and in-vivo experts to enable sufficient label uptake for (un)targeted Metabolomics analysis
  • Design metabolic quenching protocols for instantaneous arresting active metabolism in in-vitro and in-vivo samples 


Qualifications

Education & experience


  • PhD in (Analytical) Chemistry, Pharmacology or a related discipline with a strong analytical component
  • Extensive hands-on experience with modern LC-MS/MS and/or LC-High Resolution MS instrumentation and sample preparation techniques for analysis of biofluids, tissues and cellular systems
  • Practical analytical method developer and demonstrated troubleshooter
  • Practical experience with quantitative metabolomics and data evaluation packages analyzing complex data sets
  • Hands-on experience with cellular systems is a distinct advantage
  • Up to date knowledge of and practice with Liver and GI-tract metabolism
 
Competencies

  • Able to manage multiple projects in parallel with challenging timelines
  • Good communicator and team-player, both orally and in writing
  • Good interpersonal skills
  • Results driven nature
  • Hands-on attitude
 


Primary Location
Belgium-Antwerp-Beerse
Organization
Janssen Pharmaceutica N.V. (7555)
Job Function
Pharmacokinetics
Requisition ID
1805642850W