Johnson & Johnson Careers

Post-Doc Immune metabolism

Beerse, Belgium

Job Description

Requisition ID: 1805642846W

The Pharmacokinetics, Dynamics and Metabolism department of Discovery Sciences serves the various Therapeutic Area’s with ‘state-of-the-art’ analytical support in e.g. PK/PD studies, biomarker evaluation, ‘mode-of-action’ research, target binding/confirmation essay’s and conjugate analysis to support the discovery and development of (mainly) novel small molecule therapies. The department integrates metabolomics technologies in the existing High Throughput and (semi-)quantitative workflows to accelerate drug discovery and development. To support the on-going efforts to further elucidate & understand molecular mechanisms in disease, we like to strengthen our team with a

Post-Doc (2 yr’s) immune pharmacology (m/f)
  • Develop/optimize novel UPLC-MS/MS and UPLC-HR-MS methods for the analysis of selected endogenous metabolites from cellular systems, biofluids and tissue
  • Design, in collaboration with our in-vitro and in-vivo experts, Immunological relevant tracer studies focused on e.g. T-cell or macrophage differentiation
  • Design metabolic quenching protocols for instantaneous arresting active metabolism in in-vitro and in-vivo samples 

  • PhD in (Analytical) Chemistry, Pharmacology or a related discipline with a strong analytical component
  • Extensive hands-on experience with modern LC-MS/MS and/or LC-High Resolution MS instrumentation and sample preparation techniques for analysis of biofluids, tissues and cellular systems
  • Practical analytical method developer and demonstrated troubleshooter
  • Practical experience with quantitative metabolomics and data evaluation packages
  • Proven data analysis and interpretation skills of complex data sets
  • Hands-on experience with cellular systems, cell sorting technologies in the field of immunology and/or inflammation

  • Able to manage multiple projects in parallel with challenging timelines
  • Good communicator and team-player, both orally and in writing
  • Good interpersonal skills
  • Results driven nature
  • Hands-on attitude

Primary Location
Janssen Pharmaceutica N.V. (7555)
Job Function
Requisition ID