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Principal Scientist Preclinical Viral Vaccines
Requisition ID: 1805624594W
Janssen Vaccines & Prevention, one of the Janssen Pharmaceutical Companies of Johnson & Johnson, is dedicated to bringing meaningful innovation to global health. Our teams focus on the discovery, development, manufacture and marketing of vaccines and antibodies to protect people worldwide from infectious diseases.
In our organization, entrepreneurial people are working in a dynamic culture in which innovation and a 'can do' state of mind are the central points. In order to strengthen our team, we are continuously looking for enthusiastic, talented people who have the ambition to develop themselves and can be of value to Janssen. The offices of Janssen Vaccines & Prevention are located in Leiden.
In order to strengthen our Preclinical Viral Vaccines team we are looking for enthusiastic, talented people who have the ambition to develop themselves and can be of value to the organization.
Principal Scientist Preclinical Viral Vaccines
Department / project:
The Viral Vaccine discovery and translational medicine department focuses on the research and development of vaccines against viral infectious and non-infectious diseases. The Preclinical Viral Vaccines team focuses on the evaluation and characterization of novel vaccine candidates in vivo. The main focus of the team is the discovery process from pre-clinical immunology to in vivo proof of concept of various novel vaccine leads and to provide for clinical development essential non-clinical characterization of the vaccine leads. A significant part of the work is directed towards increasing our understanding of the immune response, characterization, and improvement of vaccine potency.
We are seeking a highly motivated principal scientist with at least five years of work experience after obtaining a PhD in the field of vaccines, immunology, and / or vaccine design, preferentially in an industry setting. The scientist will participate in cross functional teams to support the discovery and development of viral vaccine candidates with the aim to move these candidates towards clinical testing and/or licensure. Support of clinical testing will include studies to identify correlates of vaccine induced protection and how these can be translated to characterize human vaccine potency during early stage clinical testing to predict late stage vaccine efficacy.
The role requires profound in-depth knowledge of T cell immunology and characterization of T cell responses in various animal disease models and/or human disease which should be reflected by relevant publication history. Scientific appreciation of the complexity of immunologic pathways and responses are required. The scientist is expected to share her/his expertise also into all ongoing vaccine projects within preclinical immunology.
Specifically, this project aims to develop vaccines that induce strong T cell responses in a cross functional team. The scientist is expected to help to identify the most optimal vaccine and vaccine antigen and how to most optimally apply the vaccine. In addition, modalities how vaccine potency can be further augmented should be identified and characterized in the appropriate animal model.
The scientist will therefore be responsible for the coordination and execution of a research project to achieve the goals that are defined for the project. Excellent skills in study design, protocol writing, result documentation, evaluation and reporting, and internal/external presentation of data are required.
The role requires team player skills, self-motivation and initiative, project management skills, reliability, efficiency, flexibility and enthusiasm.
Areas of responsibility:
Plan, manage and execute research projects
Provide scientific rationale for proof of concept and supportive studies
Keep up to date with newest developments in the field and implement novel technology or readout assays
Translate research goals into action and accomplish the research target(s)
Create intellectual property
Management of a team to support the vaccine candidate evaluation
Writing scientific publications and provide input to regulatory documents
PhD with 5 year further relevant experience
Art 9 certified (Art 9 is the Dutch equivalent to FELASA C)
Understanding of vaccine manufacturing processes and immunogen design
Cross functional team thinking
Scientific skills (knowledge, accuracy, autonomy etc)
Training and communication skills
Experience in research project design
What’s in it for you…?
“Caring for the world, one person at a time…”
As an employee, we consider you as our most valuable asset. We take your career seriously. As part of a global team in an innovative environment your development is key and our day-to-day responsibility. Through e-university, on the job training, various projects and programs, we ensure your personal growth. Our benefits make sure we care for you and your family now and in the future.
Janssen Vaccines & Prevention BV (8852)