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POST DOC DISCOVERY SCIENCES
Requisition ID: 1106170514
The scientist candidate will be responsible for studying mechanisms, pathways, and therapies associated with cancer immunology.
We are seeking a highly motivated Postdoctoral Researcher to join our group at Janssen RND for 2 years. The candidate will join the Discovery Sciences Department research efforts in the characterization and development of therapeutics for the treatment of cancer. His/her responsibilities will include the design, execution and interpretation of studies for the validation and characterization of new targets and therapeutic agents.
He/she will be part of an extended team driving research on pre-clinical target identification/target validation and drug development in collaboration with our Oncology Discovery Department. He/she will explore mechanisms that enhance anti-tumor immunity and cause tumor cell killing, using primarily human and mouse tumor models and in vitro assays. Additionally, the candidate will explore underlying mechanisms of autoimmunity/immune tolerance, neo-antigen presentation, and regulation of immune activation (e.g. DCs, Tregs, T effector, T memory, and myeloid-derived suppressor cells).
The candidate will be responsible for isolating a variety of primary immune cell sub-types from human, rodent, and non-human primate products for in vitro and in vivo use in a BSL-2 environment. The ideal candidate will have a deep knowledge of flow cytometry, cell culture, and immune cell assays. Expertise in cell sorting, and retroviral/lentiviral infections is preferred. Knowledge in cancer immunology or the biology of T cells/ myeloid cells in autoimmunity is strongly preferred.
The candidate will work with key partners to generate target identification and validation data using omics and functional genomics approaches combined with in vitro cell based and mouse models. He/she will use gene editing tools such as CRISPR to investigate immune cell/target cell regulation and differentiation and to explore the impact of neo-antigens in disease. The candidate will be responsible for authoring papers documenting the work and giving presentations at appropriate conferences. The scientist will effectively and frequently collaborate with colleagues in the oncology department as well as in the medicinal chemistry and antibody development groups as needed, as well as present scientific results to multidisciplinary teams.
Primary responsibilities (include, but are not limited to):
- Demonstrate ability to design, perform and interpret complex in vitro, ex vivo and in vivo experiments
- Proficiency in Flow Cytometry assays and immune cell isolation from whole blood or tissues and cell culture is preferred.
- Proficiency in cell biology assays that could include multi-parameter FACS, ELISAs, cell proliferation, cellular cytotoxicity, antigen immunogenicity are desirable
- Demonstrate the ability to analyze and present data in professional 'publication ready' format
- Demonstrate the ability to work independently and manage multiple experiments simultaneously
- Demonstrate the ability to contribute to various projects outside of his/her own, and collaborate with stakeholders from all relevant functions
- Previous experience with IC50 determination, kinase assays, MesoScale, AlphaLISA, Luminex is desirable.
- Keep up-to-date with the literature related to his/her field.
- Demonstrate clear and professional verbal and written communication. The candidate must maintain written record of studies in the form of electronic records including notebooks, technical reports, summaries, and protocols. Once fully trained, the successful candidate will be able to work independently and manage time based on department priorities.
- Education: The ideal candidate will have a Ph.D. in cell biology, immunology or a related discipline.
- Related Experience: Strong cell biology and assay development skills are required. Knowledge of flow cytometry, cell culture, and immune cell assays is highly desirable. Experience in cancer immunology or the biology of T cells/ myeloid cells in autoimmunity is strongly preferred. A good background in cancer biology is desirable.
- Personal skills and Competencies:
- Intellectually curious and well informed on the latest scientific advances in the field
- Demonstrated creativity and novel approaches to solving scientific problems
- Excellent interpersonal skills with the ability to interact effectively with people, internally and externally
- Detail-oriented, with excellent organizational and record-keeping skills
- Excellent oral and written communication skills. Able to effectively present scientific data and concepts to international standards.
United States-Pennsylvania-Spring House
Janssen Research & Development, LLC. (6084)