Johnson & Johnson Careers

Principal Scientist, Neurodegeneration Biomarker Research

San Diego, California; Beerse, Belgium

Job Description

Requisition ID: 00001E6Q

Janssen Research and Development, L.L.C., a member of Johnson and Johnson's Family of Companies, is recruiting for a Principal Scientist, Neurodegeneration Biomarker Research, located in La Jolla, California, US or Beerse, Belgium.

You will join a team that is dedicated to addressing and solving the most meaningful unmet medical needs of our time. Motivated by our commitment to patients, we develop sustainable, integrated healthcare solutions together with our partners, based on partnerships of trust and transparency.

Janssen R&D, L.L.C. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, genetic information, national origin, protected veteran status, disability status, or any other characteristic protected by law.

You will lead biomarker research related to neurodegenerative disorders (ND), such as Alzheimer’s Disease and Parkinson’s Disease. You will work with the biomarker, discovery and experimental medicine teams and the neurodegenerative disease area leader on formulating and implementing biomarker research plans to support discovery, translation and clinical development. You will engage in the direction, planning, execution, and interpretation of biomarker related efforts in clinical trials, such as assay implementation at CROs, data collection, data QC and analysis activities. In this role, you will report to the head of neuroscience biomarkers.

You, the Principal Scientist will be responsible for the following functions:

  • Accountable for ND biomarker research in support of all compounds in Discovery, Experimental Medicine, and Clinical Development.
  • Work with discovery, translational medicine and clinical research colleagues to implement biomarker strategies that will inform and improve decision-making for the ND drug portfolio.
  • Work under limited supervision with a high level of autonomy and direct biomarker-related aspects of pre-clinical and clinical studies to effect biomarker validation and application.
  • Collaborate with the compound development teams on clinical study protocol design, development, implementation and execution related to ND projects; liaise with the clinical operations and biomarker operations teams to facilitate implementation.
  • Interact with investigational sites, clinical consultants, Contract Research Organizations (CRO) and other vendors as necessary. Monitor adherence to protocols, data quality and assess study completion.
  • Identify consultants and special scientific lecturers and arrange for them to visit; maintain multiple external relationships.
  • Handle data analysis and interpretation and communicate results to internal and external organizations.
  • Remain current on the evolving landscape of biomarker technologies and applications, study methodologies, assessment tools and relevant drug mechanisms of action.
  • Support collaborations with academic, industrial consortia, and commercial partners to optimize support of neuroscience biomarkers. 



  • A Ph.D. degree in pharmacology/biology or M.D. with experience in the neurodegenerative disease area and a minimum of 5 years of postdoctoral experience are required.
  • A scientific reputation through scientific accomplishments related to biomarkers in neurodegenerative disorders are required. This includes drafting, executing and serving as lead author on research published in peer reviewed journals, and presenting work at scientific conferences.
  • On-the-job experience with fluid and imaging biomarkers, validating links to phenotypes, and application in drug discovery, translation and clinical development is preferred.
  • Knowledge of the concepts of clinical research and drug development is required. This includes the ability to provide scientific and biomarker expertise to a clinical development program.
  • A track record in developing and implementing strategies for the technical and clinical validation of biomarkers and biomarker signatures is required.
  • Demonstrated ability to interpret biomarker data in context of phenotype data is required.
  • Strong communication, collaboration and influencing skills are required.
  • Confirmed ability to work in a team environment and to lead projects with minimal direction is required.
  • The position is located in Beerse, Belgium or La Jolla, California and may require approximately 20% travel.

Primary Location
United States-California-San Diego-
Other Locations
Europe/Middle East/Africa-Belgium-Antwerp-Beerse
Janssen Research & Development, LLC (6084)
Job Function
Requisition ID