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R&D

Scientist Antibody Screening

  • Titel Scientist Antibody Screening
  • Fungsi R&D
  • Sub Fungsi Biology
  • Location Cambridge, Massachusetts, United States
  • Posted
  • ID Permintaan 2206069405W
Melamar Sekarang
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Deskripsi

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Scientist, Antibody Screening located in Cambridge, MA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com  and follow us @JanssenGlobal. Janssen Supply Group, LLC is part of the Janssen Pharmaceutical Companies.

As a member of the Antibody Generation Group, this role will be responsible for efficiently identifying antigen-specific B cells using various antibody discovery approaches including hybridoma and single B cloning in a globally integrated environment. This is a critical function in a dynamic Biologics Discovery organization committed to bringing the next generation of biotherapeutic molecules to patients. We are looking for a motivated candidate with scientific and technical expertise who can collaborate across discovery areas to bring value to our portfolio of innovative drug concepts. If this sounds like you, come join our team!

Key Responsibilities:

  • Efficiently identifying antigen-specific B cells using various antibody discovery approaches including hybridoma and single B cloning in a globally integrated environment

  • In-depth knowledge and hands-on experience in hybridoma generation and single B cell sorting for antibody discovery are required.

  • A strong understanding of human/mouse B cell biology, immunization strategy design, immune sera evaluation and high-throughput screening will also be important.

  • Proficiency to work within a highly coordinated, fast-paced environment will be a significant attribute.

Kualifikasi

Education:

  • Ph.D. in molecular biology, biochemistry, biophysics, immunology, or a related field is required

Experience and Skills:

Required:

  • Hands-on experience in antibody generation with hybridoma or single B cell sorting approaches is required

  • Hands-on experience developing high-throughput assays for antibody screening is required

Preferred:

  • At least 1 year related experience preferred

  • Knowledge in mAb, bi-specifics and multi-specifics as therapeutics preferred

  • Experience with hybridoma electrofusion and Clonepix operation preferred

  • Flow cytometry expertise for single B cell sorting is preferred

  • Proven understanding of antibody V-gene recovery using different approaches including in-fusion cloning and next generation sequencing preferred

  • Solid understanding on microfluidics-based antibody discovery platform is preferred 

  • In-depth understanding of antibody sequence analysis including germline analysis and CDR clustering and immune repertoire analysis is preferred

  • Project Management experience, preferred

  • additional knowledge base in the areas of oncology, immunology, infectious disease, or cardiovascular disease would be a plus.

At Johnson & Johnson, we’re on a mission to change the trajectory of health for humanity. That starts by creating the world’s healthiest workforce. Through cutting-edge programs and policies, we empower the physical, mental, emotional and financial health of our employees and the ones they love. As such, candidates offered employment must show proof of COVID-19 vaccination or secure an approved accommodation prior to the commencement of employment to support the well-being of our employees, their families and the communities in which we live and work.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com.

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