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Discovery & Pre-Clinical/Clinical Development

Senior Scientist, Antibody Discovery Platform Development

  • Titre Senior Scientist, Antibody Discovery Platform Development
  • Fonction Discovery & Pre-Clinical/Clinical Development
  • Sous-fonction Biotherapeutics R&D
  • Catégorie Manager, Biotherapeutics R&D (PL7)
  • Lieu Cambridge, Massachusetts, United States
  • Date de mise en ligne
  • [Close Date]
  • Référence 2306152134W
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This job posting is anticipated to close on avr. 23 2024. The Company may however extend this time-period, in which case the posting will remain available on www.careers.jnj.com to accept additional applications.

Description

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a  Senior   Scientist, Antibody Discovery Platform Development located in Cambridge, MA.

At Janssen, we never stop working toward a future where disease is a thing of the past. We’re the Pharmaceutical Companies of Johnson & Johnson, and you can count on us to keep working tirelessly to make that future a reality for patients everywhere, by fighting sickness with science, improving access with ingenuity, and healing hopelessness with heart. We focus on areas of medicine where we can make the biggest difference: Cardiovascular & Metabolism, Immunology, Infectious Diseases & Vaccines, Neuroscience, Oncology, and Pulmonary Arterial Hypertension. Visit us: www.janssen.com

As a member of the In Vivo Antibody Discovery Group, you will be responsible for development and optimization of efficient antibody discovery platforms. As part of platform development effort, you will lead and drive the analysis of antibody repertoire from immunized animals and from enriched CHO libraries.

Responsibilities

·         Contribute to development and evaluation of emerging technologies and platforms for antibody discovery through repertoire analysis from immunized animals or CHO display library

·         Lead antibody generation using CHO display platform to screen immune repertoire

·         CHO display library preparation with targeted integration using CRISPR/Cas9 or RMCE

·         Regular presentation of data in team meeting, effective communication and coordination of work in highly matrixed project team environment

·         This will involve designing and implementing NGS experiments to generate sequence data to characterize the antibody repertoire at different stages of antibody discovery.

·         In addition to your primary responsibilities related to repertoire analysis with NGS, you may also be involved in mouse genetic engineering to improve antibody discovery efficiency.

·         This may involve techniques such as CRISPR/Cas9 gene editing to introduce specific mutations or modifications to the mouse genome.

·         A strong understanding of B-cell isolation methods such as Hybridoma technology and primary B-cell sorting will also be important.

·         This is a critical function in a multifaceted Biologics Discovery organization committed to bringing the next generation of biotherapeutic molecules to patients.

·         We are looking for a motivated candidate with scientific and technical expertise who can collaborate across discovery areas to bring value to our portfolio of innovative drug concepts.

·         Proficiency to lead within a highly coordinated, fast-paced environment will be a significant attribute.

·         An additional knowledge base in the areas of oncology, immunology, infectious disease, or cardiovascular disease would be a plus. If this sounds like you, come join our team!

Qualifications

Requirements

·       PhD in Immunology, Molecular Biology, or related field

·       Experience in antibody discovery

Preferred

·       Expertise in antibody repertoire analysis

·       Experience in cell line engineering with CRISPR technology

·       Strong background in mouse genetics and genetic engineering techniques

·       Expertise on any of different antibody discovery platforms including hybridoma, single B cell sorting, in vitro display et al.

·       Project Management experience

For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit  www.careers.jnj.com .

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability

Eligible for benefits to include medical, dental, vision and time off as well as any others as provided for in the applicable Collective Bargaining Agreement.

For additional general information on company benefits, please go to: - https://www.careers.jnj.com/employee-benefits

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