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Discovery & Pre-Clinical/Clinical Development

Scientist, RNA Process Development

  • Job Title Scientist, RNA Process Development
  • Function Discovery & Pre-Clinical/Clinical Development
  • Sub Function Biotherapeutics R&D
  • Category Senior Scientist, Biotherapeutics R&D (ST6)
  • Location San Diego, California, United States
  • Date Posted
  • Requisition Number 2406175488W
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Janssen Research & Development, LLC, a member of Johnson & Johnson's Family of Companies, is recruiting for a Scientist, RNA Process Development located in San Diego, CA.


At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at


Specifically, you will lead manufacturing and investigations supporting early phase products. You will be responsible for designing and performing laboratory analyses of manufacturing process and investigations and summarizing findings in reports. You will also coordinate and lead all aspects of technical capabilities in the laboratory, ensuring calibration, maintenance and compliance for equipment that supports our key initiatives. You will support experiments for the evaluation and implementation of new technologies (including DoE design, technology scouting, analytical testing) working closely with various partners including discovery, engineering and site technical operations. As part of an international and multidisciplinary team, you will provide summaries of data generated for project updates and founded proposals for decisions and coordinate the planning of activities in close interaction with management.


Primary Responsibilities:

·       Working closely with manufacturing site, support development of robust, scalable, and well characterized unit operations for USP and DSP procedures for short and long RNA molecules.

·       Design, complete and analyze experiments for existing and novel methods, processes, and equipment technologies.

  • Setup process equipment for lab-scale experiments.
  • Collaborate with process development and multi-functional colleagues on analytical testing and sample results.
  • Work in a team environment as well as contributing individually to meet project timelines and objectives.

·       Maintain detailed documentation through electronic lab notebooks, technical reports, and technical presentations.

·       Communicate findings to a wide audience in a timely and clear fashion.

·       Implement continuous improvement for methods, processes and/or scientific procedures.

·       Deliver reproducible and impactful results under ambitious timelines supporting development of manufacturing processes of early assets.


·       A minimum of a Bachelor’s degree in Biochemistry, Engineering, Virology, Chemistry or related scientific field is required with at least 6 years of meaningful experience; or at least 3 years of relevant experience with a Master’s degree; or 0-3 years of relevant experience with a PhD degree is required.

·       Previous experience supporting process development with RNA molecules is required.

  • Strong Knowledge of RNA or viral vector purification or chemical engineering or related scientific methodologies is highly preferred.
  • Strong knowledge of AKTA chromatography system and Unicorn software is required.

·       Hands on experience with chromatography and TFF instrumentation is required.

·       Experience in maintaining team-based Collaborations is required.

·       Must have excellent oral and written communication and presentation skills.

·       Must have strong problem-solving skills.

  • Highly organized and capable of working in a team environment with a positive attitude under limited supervision.

The anticipated base pay range for this position in all other U.S. locations is $104,000 to $166,750. 

The Company maintains highly competitive, performance-based compensation programs.  Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan.  The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/ performance year.  Bonuses are awarded at the Company’s discretion on an individual basis.

Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.

Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).

Employees are eligible for the following time off benefits:

  • Vacation - up to 120 hours per calendar year
  • Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington - up to 56 hours per calendar year
  • Holiday pay, including Floating Holidays - up to 13 days per calendar year
  • Work, Personal and Family Time - up to 40 hours per calendar year

For additional general information on company benefits, please go to:

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer.  All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. 

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