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Genomics Scientist, Translational Science, Immunology Translational Science & Medicine

  • Job Title Genomics Scientist, Translational Science, Immunology Translational Science & Medicine
  • Function R&D
  • Sub Function R&D
  • Location Spring House, Pennsylvania, United States
  • Date Posted
  • Requisition Number 2306112149W
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Janssen Research and Development, L.L.C., a member of Johnson and Johnson's Family of Companies, is recruiting for a Genomics Scientist, Translational Science (TS), Immunology Translational Science and Medicine (TSM) to be located in Spring House, PA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found. We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it.

Janssen Research & Development is a world-class pharmaceutical organization committed to research and development of innovative therapies for diseases with great unmet medical need.  Janssen Immunology Research & Development focuses on improving the health and lifestyles of people with serious immunological and inflammatory conditions worldwide, and today has a leading portfolio of medicines to treat psoriasis, Crohn’s disease, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, atopic dermatitis, and ulcerative colitis. 

To strengthen our next generation sequencing (NGS) platforms, we are seeking a creative and motivated Scientist with proven experience in advanced applications of NGS to join the Center of Excellence in Genomics within Translational Science in Immunology R&D, Early Development. Our team’s mission is to develop and evaluate assays and platforms to improve our understanding of disease biology and drug mechanism of actions (MoA) and to develop novel decision-making biomarkers for early phase clinical trials. This position is primarily laboratory-based and will be responsible for driving the development of novel methods and technologies to enable multi-omics analysis of clinical trial samples with a high degree of autonomy. Additionally, the successful candidate will provide NGS expertise to internal stakeholders in study design, execution, and troubleshooting, and partner with external service providers as needed to support high-quality data generation from clinical trial samples.

The primary responsibilities of this position are:

  • Design/execute/troubleshoot experiments to support bulk RNA-seq and single cell RNA sequencing (scRNA-seq/CITE-seq) for various clinical projects
  • Perform a wide range of cellular and molecular techniques including tissue dissociation, cell culture, flow sorting, NGS library generation and QC
  • Lead evaluation and implementation of advanced methods and technologies to enable multi-omics analysis of clinical trial samples and to provide guidance on sample collection and processing at clinical sites
  • Integrate automation (ie TECAN, Mantis, or Mosquito) to existing NGS pipelines to ensure data reproducibility and to improve throughput
  • Partner with external service providers on assays as necessary to meet project timeline and objectives
  • Perform high-level NGS data analysis and report data accurately in electronic lab notebook  
  • Work closely with other lab-based personnel within Translational Science in Immunology to ensure optimal laboratory environment (collaboration, culture, safety, etc.)



  • Ph.D. in biology, biophysics, biochemistry, bioengineering or similar field with relevant experience or M.S. with a minimum of three (3) years of NGS experience is required.
  • Extensive experience in experimental RNA/DNA methods for bulk RNA-seq and single cell RNA-seq from blood or tissue samples is required.
  • Excellent programming skills in R, Python, or similar language in a Linux environment is required.
  • Strong interpersonal and communication skills, both written and verbal, with the ability to present findings to management are required.
  • Dry and wet lab experience are required.
  • Proven ability to work successfully in multidisciplinary teams are required.
  • Ability to independently manage ongoing projects effectively with record keeping skills and meticulous attention to detail are required.
  • Deeply committed to continuous learning and staying abreast of scientific advances are required.


  • Experience with illumina sequencers (i.e. NovaSeq) is preferred.
  • Experience with various scRNA-seq workflows is preferred.
  • Experience with tissue-based assays and flow cytometry is preferred.
  • Experience with tissue disassociation methods is preferred.
  • Experience with robotics/automation is preferred.
  • Prior experience in the biotechnology or pharmaceutical industry is preferred.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.


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